{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T01:07:12Z","timestamp":1774832832939,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Therapy for relapsed or refractory (R\/R) aggressive B\u2010cell non\u2010Hodgkin lymphoma (aB\u2010NHL) post autologous stem cell transplantation (ASCT) or in elderly patients can be challenging. In this single\u2010center, single\u2010arm, phase II clinical study, we investigated the efficacy of ibrutinib (560\u00a0mg once daily) in combination with bendamustine and rituximab (IBR) given for six 28\u2010day cycles in their standard dose, to patients with R\/R aB\u2010NHL who were either transplant ineligible in first or second relapse or post\u2010ASCT for second relapse. The primary endpoint was overall response rate (ORR). Fifty\u2010six patients (54% male, median age 69.7\u00a0years) were included. ORR was 49.1% among 55 patients treated with \u2265 1 cycle of IBR and 69.4% among 36 patients treated with \u2265 3 cycles. Patients with relapsed disease had significantly higher ORR compared to those with refractory disease (72.3% vs. 37.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.024). Median overall survival (OS) was 11.6\u00a0months (95% CI, 7.1\u201322.3) and median progression\u2010free survival was 5.3\u00a0months (95% CI, 2.5\u20137.4). Patients with complete and partial responses had significantly longer median OS compared to those with stable and progressive disease (28.1 vs. 5.2\u00a0months, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Adverse events included thrombocytopenia (19.6%), anemia (16.1%), neutropenia (7.1%), fatigue (35.7%), diarrhea (28.6%) and nausea (28.6%). At the first efficacy evaluation 8 patients were referred to transplantation, and 3 more were referred during follow\u2010up. These data indicate that the IBR regimen is a safe and effective treatment option that can also be used for bridging to transplantation in patients with R\/R aB\u2010NHL.<jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT02747732<\/jats:p>","DOI":"10.1002\/hon.70001","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T03:25:24Z","timestamp":1732245924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ibrutinib With Bendamustine and Rituximab for Treatment of Patients With Relapsed\/Refractory Aggressive B\u2010Cell Lymphoma"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-8551","authenticated-orcid":false,"given":"Meirav","family":"Kedmi","sequence":"first","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Chaim Sheba Medical Center  Ramat Gan Israel"},{"name":"Faculty of Medical &amp; 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Health Sciences School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Pathology Chaim Sheba Medical Center  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Raskin","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Chaim Sheba Medical Center  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Eshet","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Chaim Sheba Medical Center  Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramit","family":"Mehr","sequence":"additional","affiliation":[{"name":"The Mina &amp; Everard Goodman Faculty of Life Sciences Bar\u2010Ilan University  Ramat\u2010Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Netanel","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplant Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Gurion","sequence":"additional","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center Rabin Medical Center  Petah\u2010Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neta","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chava","family":"Perry","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; 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