{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:45:23Z","timestamp":1791895523359,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In elderly patients with high\u2010risk classic Hodgkin lymphoma (c\u2010HL), we evaluated the impact of a new modality treatment without bleomycin, that is, liposomal doxorubicin (NPLD)\u2010based regimen plus consolidation radiotherapy of residual nodal masses (RNMs), on overall survival (OS) and progression free survival (PFS). In this retrospective study (2013\u20132023) conducted in tertiary hospitals in the bay of Naples (Italy), 50 older adults (median age, 69\u00a0years; range, 60\u201389) with advanced stage c\u2010HL received frontline treatment with MVD\u00a0\u00b1\u00a0irradiation. MVD consisted of 25\u00a0mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    of NPLD along with standard Vinblastine and Dacarbazine for a total of 6 cycles (twelve iv administrations, every 2\u00a0weeks) followed by radiation of RNMs with size \u2265\u00a02.5\u00a0cm at computed tomography. Patients underwent MVD with a median dose intensity of 92%. At 2\u2010deoxy\u20102[F\u201018] fluoro\u2010D\u2010glucose positron emission tomography (FDG\u2010PET), 90% of patients (45\/50 patients; one failed to perform final FDG\u2010PET due to early death) reached complete responses. Altogether, 17 patients (34%) received consolidation radiotherapy of RNMs with Deauville score \u2265 3. At 5\u2010year median follow\u2010up, the OS and PFS of the entire population were 87.5% (95% confidence interval [CI], 78.7\u201397.4) and 81.6% (95% CI, 71.4\u201393.2), respectively. Eleven patients (22%) experienced grade \u2265 3 adverse events, and 4 of them required hospitalization. Our data suggest that in older adults with high\u2010risk c\u2010HL NPLD\u2010driven strategy (without bleomycin) plus consolidation radiotherapy (if needed) may be a promising up\u2010front option, to test in phase II clinical trials for improving survival incidence.\n                  <\/jats:p>","DOI":"10.1002\/hon.70003","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T02:40:05Z","timestamp":1731897605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Liposomal Doxorubicin, Vinblastine and Dacarbazine Plus Consolidation Radiotherapy of Residual Nodal Masses for Frontline Treatment in Older Adults With Advanced Stage Classic Hodgkin Lymphoma: Improved Outcome in a Multi\u2010Center Real\u2010Life Study"],"prefix":"10.1002","volume":"42","author":[{"given":"M.","family":"Picardi","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vincenzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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