{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:27:02Z","timestamp":1788877622363,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphoma (MCL) is an aggressive non\u2010Hodgkin lymphoma with poor prognosis. The usefulness of fluorine\u201018\u2010fluorodeoxyglucose positron emission tomography\/computed tomography (2\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET\/CT) and its parameters in the evaluation of treatment response and prognosis is not yet clear. The aim of this study was to investigate the prognostic role of tumor burden and tumor dissemination features derived by 2\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET\/CT in advanced MCL. We retrospectively included 120 patients with advanced MCL who underwent baseline 2\u2010 2\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET\/CT and end\u2010of\u2010treatment (eot) PET\/CT. The baseline\u2010PET images were analyzed visually and semi\u2010quantitatively by measuring the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and dissemination features (Dmax and Dmax\u2010bsa). EotPET\/CT was judged according to the Lugano classification. Progression\u2010free survival (PFS) and overall survival (OS) were plotted according to the Kaplan\u2013Meier method. At a median follow\u2010up of 59\u00a0months, relapse\/progression occurred in 68 patients while death in 38 patients with a median PFS and OS of 27.2 and 57.6\u00a0months, respectively. MIPI score, Bulky disease, Ki\u201067 index, metabolic response, pretreatment MTV and TLG were significantly associated with PFS at univariate analysis, but only metabolic response, MTV and TLG were confirmed to be independent prognostic factors. Considering OS, only dissemination features were demonstrated to be prognostic features. In conclusions, metabolic response and metabolic tumor burden parameters (MTV and TLG) are strongest predictor of PFS, while dissemination features may have a significant role for predicting OS.\n                  <\/jats:p>","DOI":"10.1002\/hon.70009","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T01:49:53Z","timestamp":1732931393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic Role of Pretreatment Tumor Burden and Dissemination Features From 2\u2010[\n                    <sup>18<\/sup>\n                    F]FDG PET\/CT in Advanced Mantle Cell Lymphoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-6494","authenticated-orcid":false,"given":"Domenico","family":"Albano","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department ASST Spedali Civili Brescia  Brescia Italy"},{"name":"Universit\u00e0 degli Studi di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Bianchetti","sequence":"additional","affiliation":[{"name":"Division of Hematology ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Talin","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Dondi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department ASST Spedali Civili Brescia  Brescia Italy"},{"name":"Universit\u00e0 degli Studi di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Re","sequence":"additional","affiliation":[{"name":"Division of Hematology ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Tucci","sequence":"additional","affiliation":[{"name":"Division of Hematology ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertagna","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department ASST Spedali Civili Brescia  Brescia Italy"},{"name":"Universit\u00e0 degli Studi di Brescia  Brescia 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