{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:23:58Z","timestamp":1785900238458,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta\u20102\u2010microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first\u2010line immunochemotherapy. We analyzed 125 patients with the following characteristics: median age, 61\u00a0years (55; 67), advanced\u2010stage disease, 88.8%; high FLIPI, 49.6%; TMTV, &gt; 510\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    ; B2M, &gt; 3\u00a0mg\/L (24.8%); and R\u2010CHOP\u2010like treatment, 86.4%. We defined the following categories: low\u2010risk (36%), TMTV \u2264 510\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    and B2M\u00a0\u2264\u00a03\u00a0mg\/L; intermediate\u2010risk (45.6%), TMTV &gt; 510\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    or B2M &gt; 3\u00a0mg\/L; and high\u2010risk (18.4%), TMTV &gt; 510\u00a0cm\n                    <jats:sup>3<\/jats:sup>\n                    and B2M &gt; 3\u00a0mg\/L. The 5\u2010year overall survival rates were estimated to be 96.1%, 89.1% and 73.7% for low\u2010, intermediate\u2010 and high\u2010risk patients, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003). Patients at intermediate and high risk according to the TMTV\/B2M score were at high risk of disease progression within 24\u00a0months of treatment initiation (HR\u00a0=\u00a02.45 [95% CI: 1.23\u20134.85] and HR\u00a0=\u00a03.75 [95% CI: 1.7\u20138.2], respectively). This TMTV\/B2M score may identify patients with the highest unmet medical needs.\n                  <\/jats:p>","DOI":"10.1002\/hon.70010","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:24:33Z","timestamp":1734323073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combining Total Metabolic Tumor Volume With Beta\u20102\u2010Microglobulin Levels Predicts Outcomes in High\u2010Burden Follicular Lymphoma Patients"],"prefix":"10.1002","volume":"43","author":[{"given":"A.","family":"Zduniak","sequence":"first","affiliation":[{"name":"Department of Hematology Centre Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"L\u00e9v\u00eaque","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Centre Henri Becquerel  Rouen 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