{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:53Z","timestamp":1772118653983,"version":"3.50.1"},"reference-count":76,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite the study of\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010positive and \u2010negative myeloproliferative neoplasms (MPNs) providing seminal insights into cancer biology, tumor evolution and precision oncology over the past half century, significant challenges remain. MPNs are clonal hematopoietic stem cell\u2010derived neoplasms with heterogenous clinical phenotypes and a clonal architecture which impacts the often\u2010complex underlying genetics and microenvironment. The major driving molecular abnormalities have been well characterized, but debate on their role as disease\u2010initiating molecular lesions continues. The introduction of the ABL1 tyrosine kinase inhibitors have been extremely successful in the treatment of chronic myeloid leukemia with most patients having a near\u2010normal life expectancy. Similar success has, however, not been achieved for\n                    <jats:italic>BCR::ABL1<\/jats:italic>\n                    \u2010negative MPNs in terms of disease course modification and most patients remain incurable. In both disease categories, genomic instability seems to increase the risk of disease progression to accelerated\/blast phase, which is resistant\/refractory to conventional treatment and associated with a poor prognosis. To address some of these issues, the late John Goldman and Tariq Mughal founded a scientific and clinical platform in 2006, the Post\u2010American Society of Hematology (ASH) MPN workshop, to appraise novel cancer biology, candidate therapeutic targets, treatments and other clinical challenges and pay tribute to all the many scientists and clinicians around the world instrumental to the progress made and continuing advances being made. This paper summarizes some of the recent data discussed at the 18\n                    <jats:sup>th<\/jats:sup>\n                    edition of the workshop and includes reference to some data presented or published after the workshop, including the 26\n                    <jats:sup>th<\/jats:sup>\n                    John Goldman CML conference.\n                  <\/jats:p>","DOI":"10.1002\/hon.70013","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T09:14:02Z","timestamp":1737191642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Recent Translational and Therapeutic Developments on Clinical Course of\n                    <i>BCR::ABL1\u2010<\/i>\n                    Positive and \u2010Negative Myeloproliferative Neoplasms"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-7724","authenticated-orcid":false,"given":"Tariq I.","family":"Mughal","sequence":"first","affiliation":[{"name":"Tufts University Medical Center  Boston Massachusetts USA"},{"name":"Beckmann Research Institute of City of Hope  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raajit K.","family":"Rampal","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prithviraj","family":"Bose","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lion","sequence":"additional","affiliation":[{"name":"St.Anna Children's Cancer Research Institute  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ajufo","sequence":"additional","affiliation":[{"name":"John T. 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