{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:19:08Z","timestamp":1790864348584,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Polatuzumab vedotin plus R\u2010CHP (Pola\u2010R\u2010CHP) is approved as a new standard first\u2010line therapy for diffuse large B\u2010cell lymphoma (DLBCL) based on the POLARIX trial. However, real\u2010world data on its efficacy and safety in unselected patients is lacking. We conducted a retrospective cohort study to evaluate Pola\u2010R\u2010CHP versus R\u2010CHOP outcomes in routine clinical practice in China. This is a multi\u2010institutional retrospective cohort study and included all consecutive patients that received at least one dose of polatuzumab vedotin up until February 2024. A total of 600 eligible patients from 6 centers were identified, 131 receiving Pola\u2010R\u2010CHP and 469 R\u2010CHOP. After 1:2 propensity score matching, 128 pairs were obtained for further survival and prognosis analysis. With a median follow\u2010up of 12.8\u00a0months, 12\u2010month progression\u2010free survival (PFS) was numerically higher with Pola\u2010R\u2010CHP versus R\u2010CHOP (90.3% vs. 84.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.18). Benefits were consistently observed across molecular subgroups, especially advanced stage, ECOG \u2265 2, extranodal involvement \u2265 2 and non\u2010GCB group. The complete response rate of the Pola\u2010R\u2010CHP group was higher than that of the RCHOP group (86.8% vs. 79.7%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.09), but there was no statistical difference. Safety profiles were comparable, with no new concerns. Among 128 patients treated with Pola\u2010R\u2010CHP, 96 underwent gene sequencing analysis: MCD (25.0%), EZB (13.5%), combined subtype (12.5%), ST2 (9.4%), and other\/unclassifiable subtype (30.2%). The most common mutations (&gt; 25% of cases) were PIM1, TP53, BCL\u20106, KMT2D, SOCS1, BCL\u20102. Genetic testing results show the correlation between genotyping, gene mutations in PIM1\/TP53 and therapeutic efficacy. This large real\u2010world study supports Pola\u2010R\u2010CHP as an effective frontline option for DLBCL, with sustained efficacy versus R\u2010CHOP observed in unselected populations. While 12\u2010month PFS failed to reach statistical significance, subgroup analyses favor Pola\u2010R\u2010CHP. Further research with a wider population, longer follow\u2010up, and screening of advantageous groups are warranted.<\/jats:p>","DOI":"10.1002\/hon.70017","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T11:23:45Z","timestamp":1733484225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy and Safety of Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Previously Untreated Diffuse Large B\u2010Cell Lymphoma: A Real\u2010World, Multi\u2010Center, Retrospective Cohort Study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-5679","authenticated-orcid":false,"given":"Peiqi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Lymphoma Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy National Clinical Research Center for Cancer Tianjin 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