{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:56:55Z","timestamp":1788753415045,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The negative impact of invasive pulmonary aspergillosis (IPA) in acute myeloid leukemia (AML) is well known whereas its clinical relevance in acute lymphoid leukemia (ALL) is still unclear. We have carried out a prospective multicentric observational study within the Rete Ematologica Lombarda to describe the incidence of IPA in acute leukemia (AL) patients, focusing on differences between AML and ALL. Between 2018 and 2020, 207 AL patients (AML: 165, ALL: 42) were evaluated. During induction, proven\/probable and possible IPA were diagnosed in 32\/207 patients (15.4%), equally divided into proven\/probable and possible (16 each, 7.7%). IPA diagnosis was made in 23\/165 (13.9%) AML and in 9\/42 (21.4%) ALL patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.2374). Proven\/probable IPA were more frequent in ALL than in AML (ALL: 7\/42, 16.6% vs. AML: 9\/165, 5.4%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0235). OS was similar in patients with or without proven\/probable IPA (not reached vs. 63\u00a0months,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.588), while OS was significantly reduced in possible IPA (22\u00a0months vs. not reached,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0167). More than 15\u00a0days of neutropenia duration and lack of antimold prophylaxis were associated with IPA. Achieving complete remission was protective, whereas age over 60\u00a0years and, with a borderline significance, possible IPA were associated with risk of death. In conclusion, Ph\u2010negative ALL should be considered at the same high risk for IPA as AML. Antimold prophylaxis should be probably extended also to ALL.\n                  <\/jats:p>","DOI":"10.1002\/hon.70045","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T14:23:26Z","timestamp":1739370206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Different Epidemiology of Invasive Pulmonary Aspergillosis in Acute Lymphoblastic Leukemia in Comparison With Acute Myeloid Leukemia: Results of a Prospective Multicentric Observational Study of the Rete Ematologica Lombarda"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-3237","authenticated-orcid":false,"given":"C.","family":"Cattaneo","sequence":"first","affiliation":[{"name":"Hematology ASST\u2010Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bernardi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Scientifico San Raffaele Unit\u00e0 Operativa di Ematologia e TMO  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-8690","authenticated-orcid":false,"given":"N.","family":"Fracchiolla","sequence":"additional","affiliation":[{"name":"Hematology Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pagani","sequence":"additional","affiliation":[{"name":"Hematology ASST\u2010Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gigli","sequence":"additional","affiliation":[{"name":"Division of Oncohematology IEO Istituto Europeo di Oncologia IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Basilico","sequence":"additional","affiliation":[{"name":"Hematology ASST\u2010Settelaghi  Varese 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 Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Todisco","sequence":"additional","affiliation":[{"name":"Hematology ASST\u2010Valle Olona  Busto Arsizio 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