{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:26:05Z","timestamp":1772547965611,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n This study aims to focus on GM at species level, exploring the causal associations with different kinds of lymphoma to provide some information on potential intervention directions in lymphoma. Data of GM taxa were extracted from the genome\u2010wide association study conducted by the MiBioGen and Dutch Microbiome Project (DMP), and those of lymphomas were obtained from the FinnGen consortium. Inverse variance weighted (IVW) method and Bonferroni multiple correction were utilized to assess the causal associations of GM species with different kinds of lymphoma. The effect size was expressed by odds ratios (ORs) with 95% confidence intervals (CIs). Reverse causal association analysis has also been performed. Additionally, scatter plots and leave\u2010one\u2010out test were conducted for sensitivity analysis. After correction, the IVW estimates suggested that elevated relative abundance of species\n Faecalibacterium_prausnitzii<\/jats:italic>\n had a negatively causal association with increased odds of Hodgkin's lymphoma (HL) (OR\u00a0=\u00a00.584, 95% CI: 0.516\u20130.662). Relative abundance of species\n Gordonibacter_pamelaeae<\/jats:italic>\n ,\n Holdemania_filiformis<\/jats:italic>\n ,\n Sutterella_wadsworthensis<\/jats:italic>\n and\n Coprococcus_sp_ART55_1<\/jats:italic>\n was negatively associated with follicular lymphoma (FL) odds, whereas that of species\n Bifidobacterium_catenulatum<\/jats:italic>\n and\n Coprococcus_comes<\/jats:italic>\n were positively associated with FL odds (all\n p<\/jats:italic>\n \u00a0<\u00a00.05). Relative abundance of species\n Akkermansia_muciniphila<\/jats:italic>\n and\n Coprococcus_sp_ART55_1<\/jats:italic>\n had a negatively causal association with non\u2010follicular lymphoma (NFL) odds, respectively, while that of\n Bacteroides_uniformis<\/jats:italic>\n had a positive one (all\n p<\/jats:italic>\n \u00a0<\u00a00.05). Relative abundance of species\n Flavonifractor_plautii<\/jats:italic>\n was negatively linked to diffuse large B\u2010cell lymphoma (DLBCL) risk (OR\u00a0=\u00a00.471, 95% CI: 0.344\u20130.645). Relative abundance of species\n Eggerthella_unclassified<\/jats:italic>\n was positively associated with T\/NK cell lymphoma (TNK) risk while that of\n Ruminococcus_lactaris<\/jats:italic>\n was negatively associated with TNK risk (all\n p<\/jats:italic>\n \u00a0<\u00a00.05). Elevated relative abundance of\n Parabacteroides_unclassified<\/jats:italic>\n was associated with higher risk of non\u2010Hodgkin's lymphoma (NHL) (OR\u00a0=\u00a01.955, 95% CI: 1.654\u20132.312). The relative abundance of species\n Holdemania_filiformis<\/jats:italic>\n was negatively associated with mantle cell lymphoma (MCL) risk (OR\u00a0=\u00a00.637, 95% CI: 0.544\u20130.746). The relative abundance of species\n Rothia_mucilaginosa<\/jats:italic>\n and\n Lachnospiraceae_bacterium_3_1_46FAA<\/jats:italic>\n had positively causal association with marginal zone lymphoma (MZL) risk, while that of species\n Alistipes_senegalensis<\/jats:italic>\n had a negative one (all\n p<\/jats:italic>\n \u00a0<\u00a00.05). This study identified 16 GM species that have potential causal associations with different kinds of lymphoma, which provided some new idea for further exploration on prevention and treatment targets in lymphoma.\n <\/jats:p>","DOI":"10.1002\/hon.70046","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T06:34:16Z","timestamp":1739514856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Causal Associations of Gut Microbiota Species With Lymphoma: A Two\u2010Sample Mendelian Randomization Study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-7361","authenticated-orcid":false,"given":"Mei","family":"Li","sequence":"first","affiliation":[{"name":"Tianjin University Tianjin China"},{"name":"Pediatrics Department The Fourth Hospital of Hebei Medical University HeBei 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