{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:21:53Z","timestamp":1787242913940,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myelofibrosis (MF) is characterized by anemia, constitutional symptoms, hepatosplenomegaly and bone marrow fibrosis, and is associated with poor survival. The janus kinase inhibitor (JAKi) ruxolitinib has been the mainstay of treatment for over a decade. Despite demonstrated symptomatic and quality of life improvement, unmet clinical needs persist. A literature review identified promising novel targeted treatment options in MF using pre\u2010set selection criteria (available Phase 2 or 3 data, minimum enrollment of 50 patients, trial end date within the last 5\u00a0years). Available data for novel and approved therapies were extracted, tabulated, and analyzed for clinical relevancy. From an initial shortlist of 48, 16 retained molecules were selected for inclusion. Other JAKi (pacritinib, momelotinib, jaktinib) address treatment\u2010related cytopenia, expanding the therapeutic utility of this class of agents to patients with baseline anemia or thrombocytopenia. Novel candidates exploit multiple molecular pathways, and offer the potential to improve the management of MF\u2010associated cytopenia (imetelstat, pelabresib, navitoclax, selinexor, luspatercept, sotatercept, elritercept, LCL161, bomedemstat) and recover bone marrow fibrosis (imetelstat, pelabresib, navitoclax and bomedemstat). It remains to be seen if these newer agents can induce any remission in MF and enable patients to come off therapy, but the future is beginning to look much brighter.<\/jats:p>","DOI":"10.1002\/hon.70053","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T10:36:45Z","timestamp":1744022205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Managing Myelofibrosis: Matching Advances in Treatments With Clinical Unmet Needs"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2283-5158","authenticated-orcid":false,"given":"Tze Wei","family":"Chan","sequence":"first","affiliation":[{"name":"MOH Holdings Pte Ltd  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-083X","authenticated-orcid":false,"given":"Hein","family":"Than","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9546-3850","authenticated-orcid":false,"given":"Feng\u2010Ju","family":"Huang","sequence":"additional","affiliation":[{"name":"Novartis Singapore Pte Ltd  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9125-3844","authenticated-orcid":false,"given":"Gauri","family":"Billa","sequence":"additional","affiliation":[{"name":"Novartis Singapore Pte Ltd  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-7296","authenticated-orcid":false,"given":"Lai Heng","family":"Lee","sequence":"additional","affiliation":[{"name":"MOH Holdings Pte Ltd  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1992756"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.89"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26857"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16071416"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27274"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2196593"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1110557"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1110556"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17727"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25777"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(17)30027\u20103"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.5818"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.73.4418"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(17)30237\u20105"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5799"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(22)02036\u20100"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899\u2010024\u201000744\u20109"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001471\u2010z"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001637\u20107"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010163456"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2023.41.16_suppl.7015"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010201642"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102022\u20100235"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010179141"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2024.42.16_suppl.6502"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010173509"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26709"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102022\u20100901"},{"key":"e_1_2_12_30_1","volume-title":"KRT\u2010232, A First\u2010In\u2010Class, Murine Double Minute 2 Inhibitor (MDM2I), for Myelofibrosis (MF) Relapsed or Refractory (R\/R) to Janus\u2010Associated Kinase Inhibitor (JAKI) Treatment (TX)","author":"Al\u2010Ali H. 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