{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:04:57Z","timestamp":1787785497823,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diffuse large B cell lymphoma (DLBCL) is a type of common and fatal non\u2010Hodgkin lymphoma. This study aimed to detect the specific function of lncRNA ARAP1\u2010AS1 in DLBCL. The in vitro experiments were performed using RT\u2010qPCR, western blotting, MTT, colony formation, flow cytometry analysis, FISH, RNA pulldown, and luciferase reporter assays. A xenograft mouse model was used to evaluate tumor growth in vivo. ARAP1\u2010AS1 expression was upregulated in DLBCL tissues and cells. ARAP1\u2010AS1 knockdown inhibited DLBCL cell proliferation and promoted apoptosis. ARAP1\u2010AS1 activated PI3K\/AKT signaling by upregulating EMP1 expression via miR\u2010508\u20135p. EMP1 overexpression markedly abolished the effect of ARAP1\u2010AS1 knockdown on DLBCL cell proliferation and apoptosis, and PI3K inhibitor reversed the effect of ARAP1\u2010AS1 overexpression on DLBCL cells. ARAP1\u2010AS1 knockdown inhibited DLBCL tumor growth and reduced Ki\u201067, EMP1, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AKT expression in xenograft mouse models. ARAP1\u2010AS1 knockdown exerts anti\u2010tumor effect on DLBCL progression through the miR\u2010508\u20135p\/EMP1\/PI3K\/AKT axis.\n                  <\/jats:p>","DOI":"10.1002\/hon.70056","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:46:02Z","timestamp":1744623962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["ARAP1\u2010AS1 Overexpression Increases Diffuse Large B Cell Lymphoma Progression by Sponging miR\u2010508\u20135p to Activate the EMP1\u2010PI3K\/AKT Pathway"],"prefix":"10.1002","volume":"43","author":[{"given":"Yamei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Hematology The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oncology The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9222-5822","authenticated-orcid":false,"given":"Dongyun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology The Dongtai Hospital of Nantong University  Dongtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26717"},{"issue":"7","key":"e_1_2_10_3_1","first-page":"707","volume":"43","year":"2021","journal-title":"Zhonghua zhong liu za zhi [Chinese journal of oncology]"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.09.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.56.79"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1804980"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.08.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.07.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.040"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20101886\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24680"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20101479\u20103"},{"issue":"4","key":"e_1_2_10_13_1","first-page":"1815","article-title":"Increased Long Non\u2010coding RNA ARAP1\u2010AS1 Expression and its Prognostic Significance in Human Gastric Cancer: A Preliminary Study","volume":"24","author":"Jiang Y. 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