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After achieving regulatory approval in third line (3L+), randomized trials confirmed superiority over standard\u2010of\u2010care salvage chemoimmunotherapy (CIT) and autologous stem\u2010cell transplantation in patients experiencing progressive disease within 12\u00a0months of first\u2010line treatment. On the other hand, bispecific antibodies (BsAbs) are approved in the 3L+, while trials are exploring their potential in an earlier setting, usually in combination with CIT. In follicular lymphoma (FL), both T\u2010cell redirecting strategies are approved in 3L+. The higher response rate with CAR T cells in FL comes at the cost of an increased toxicity risk and logistical barriers, in comparison with off\u2010the\u2010shelf BsAbs. This review focuses on the role of CAR T cells and BsAbs in LBCL and FL, paying special attention to available results and sequencing approaches.<\/jats:p>","DOI":"10.1002\/hon.70068","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T17:50:15Z","timestamp":1750009815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["T\u2010Cell Redirecting Strategies in Large B\u2010Cell Lymphoma and Follicular Lymphoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-9288","authenticated-orcid":false,"given":"Gloria","family":"Iacoboni","sequence":"first","affiliation":[{"name":"Department of Hematology Vall d'Hebron University Hospital  Barcelona Spain"},{"name":"Experimental Hematology Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.01992"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.12.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.08.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020578"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011767"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03084-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2401361"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-24-1798"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2116133"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2116596"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(22)00662-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2301665"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018730"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02572-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(22)00339-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1707447"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1804980"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31366-0"},{"issue":"19","key":"e_1_2_8_21_1","first-page":"2307","article-title":"Five\u2010Year Follow\u2010Up of ZUMA\u20101 Supports the Curative Potential of Axicabtagene Ciloleucel in Refractory Large B\u2010Cell Lymphoma","volume":"141","author":"Neelapu S. 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