{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:47:18Z","timestamp":1792676838198,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Nodular lymphocyte\u2010predominant B\u2010cell\/Hodgkin lymphoma (NLPB\/HL) accounts for roughly 5% of all Hodgkin lymphoma (HL) cases. In contrast to classic HL (cHL), the malignant cells in NLPB\/HL lack CD30 expression but maintain a complete phenotype of mature B\u2010cells including CD20 and IgG, but occasionally show IgD expression. The tumor cells are known as lymphocyte\u2010predominant (LP) cells and grow in a T\u2010cell and histiocyte rich microenvironment against a background of follicular dendritic cells. Transformation to large B cell lymphoma may occur and requires excisional lymph node biopsies. Most patients with NLPB\/HL present in early stages. The disease usually has an indolent clinical course. Approaches applied in cHL result in very good outcomes with only limited excess mortality in comparison with the general population. Activity has also been demonstrated for rituximab\u2010containing regimens commonly used in indolent B\u2010cell non\u2010Hodgkin lymphoma. The present article reviews pathological characteristics, treatment options and tools that might improve risk stratification in NLPB\/HL.<\/jats:p>","DOI":"10.1002\/hon.70080","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T17:52:51Z","timestamp":1750009971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nodular Lymphocyte\u2010Predominant Hodgkin Lymphoma: Update on Biology and Treatment"],"prefix":"10.1002","volume":"43","author":[{"given":"Peter","family":"Borchmann","sequence":"first","affiliation":[{"name":"<!--Query ID=\"q2\" Text=\"AUTHOR: Please provide received date.\"--> First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne  Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Eichenauer","sequence":"additional","affiliation":[{"name":"<!--Query ID=\"q2\" Text=\"AUTHOR: Please provide received date.\"--> First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne  Cologne Germany"},{"name":"German Hodgkin Study Group (GHSG) University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Frigola","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Hospital Clinic Barcelona University of Barcelona  Barcelona Spain"},{"name":"Institute for Biomedical Research August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Hospital Clinic Barcelona University of Barcelona  Barcelona 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