{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:21:46Z","timestamp":1783812106565,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Relapse and refractory T\u2010cell acute lymphoblastic leukemia and lymphoblastic lymphoma (R\/R T\u2010ALL\/LBL) patients have poor outcomes. Chimeric antigen receptor (CAR)\u2010T\u2010cell therapy for T\u2010ALL\/LBL has shown encouraging results in the early stages of clinical trials. Here, we retrospectively analyzed the outcomes of 12 patients with R\/R T\u2010ALL\/LBL who received CD7 CAR\u2010T cell therapy. Eleven patients received autologous CAR\u2010T cells, while one patient received allogeneic CAR\u2010T cells. On Day 28 post\u2010infusion, 67% (8\/12) of patients achieved an overall response (ORR). At a median follow\u2010up of 134 (14\u2013925) days, the median overall survival (OS) was 134\u00a0days, and the progression\u2010free survival (PFS) was 81\u00a0days. Among the 8 patients who achieved remission after CD7 CAR\u2010T cell infusion, 5 patients received consolidation allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Compared with 3 patients who did not undergo consolidation allo\u2010HSCT, patients with allo\u2010HSCT as consolidation showed a trend toward better OS (allo\u2010HSCT vs. control: 6\u2010month OS, 60% vs. 33.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.073) and better PFS (allo\u2010HSCT vs. control: 6\u2010month PFS, 60% vs. 0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.022). Cytokine release syndrome (CRS) occurred in all patients (grade 1\u20132 in 67% of patients, grade 3 in 33% of patients), and one patient experienced neurotoxicity. CD7 CAR\u2010T cell therapy is a promising option for R\/R T\u2010ALL\/LBL patients with manageable adverse events. Moreover, CD7 CAR\u2010T cell infusion followed by consolidation allo\u2010HSCT in R\/R T\u2010ALL\/LBL patients might play an important role in prolonging remission duration.\n                  <\/jats:p>","DOI":"10.1002\/hon.70081","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:34:51Z","timestamp":1744623291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Outcomes of CD7 CAR\u2010T Cell Therapy in Relapsed or Refractory T\u2010Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Patients"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8589-0692","authenticated-orcid":false,"given":"Jinyan","family":"Xiao","sequence":"first","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-3546","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-972X","authenticated-orcid":false,"given":"Suning","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7891","authenticated-orcid":false,"given":"Xiaowen","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Cyrus Tang Medical Institute Collaborative Innovation Center of Hematology State Key Laboratory of Radiation Medicine and Protection Soochow University  Suzhou China"},{"name":"PersonGen BioTherapeutics (Suzhou) Co. 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Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depei","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"353","article-title":"The Consensus of the Diagnosis and Treatment of Adult T\u2010Cell Lymphoblastic Lymphoma in China (2023)","volume":"44","year":"2023","journal-title":"Zhonghua xue ye xue za 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