{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:30:26Z","timestamp":1772983826594,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Given the paucity of age\u2010specific data about biology, presentation, and treatment outcomes in adults with MZL, we sought to evaluate differences between younger (\u2264 70\u00a0years) and older (&gt; 70\u00a0years) patients with MZL in a large retrospective cohort treated in the contemporary era (2010 onwards). The primary objective was progression\u2010free survival (PFS), while secondary objectives included the evaluation of overall survival (OS) and the cumulative incidence of transformation between the 2 groups. A total of 598 patients were included in the analysis and among these 32% were &gt; 70\u00a0years of age. There were no age\u2010based differences in the prevalence of NMZL, SMZL, and EMZL. Older patients had a higher incidence of adverse prognostic features at diagnosis such as worse performance status, advanced stage disease, and bone marrow involvement, yet were more likely to be treated with single\u2010agent rituximab than chemoimmunotherapy. Age &gt; 70\u00a0years was associated with inferior PFS and OS after controlling for clinically relevant risk factors and accounting for differences in first\u2010line treatment. Receipt of rituximab monotherapy was associated with significantly inferior PFS overall, however, the type of first\u2010line therapy did not impact OS in any group. Our data suggests that despite the development of new drugs for MZL, age remains an independent predictor of inferior outcomes. Investigation of targeted therapy combinations in the first\u2010line setting may yield the required balance of efficacy and toxicity in older adults with MZL.<\/jats:p>","DOI":"10.1002\/hon.70087","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T08:15:17Z","timestamp":1745309717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Age on Biology, Presentation and Outcomes in Marginal Zone Lymphoma: Results From a Multicenter Cohort Study"],"prefix":"10.1002","volume":"43","author":[{"given":"Pallawi","family":"Torka","sequence":"first","affiliation":[{"name":"Department of Medicine Roswell Park Comprehensive Cancer Center  Buffalo New York USA"},{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie S.","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Medicine Lineberger Comprehensive Cancer Center University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-6454","authenticated-orcid":false,"given":"Timothy J.","family":"Voorhees","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0984-4376","authenticated-orcid":false,"given":"Reem","family":"Karmali","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin","family":"Annunzio","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus P.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Medicine Siteman Cancer Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Anampa\u2010Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Medicine Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Reves","sequence":"additional","affiliation":[{"name":"Department of Medicine Harold C. Simmons Comprehensive Cancer Center UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montreh","family":"Tavakkoli","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Christian","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Medicine Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan K.","family":"Barta","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen Ramakrishnan","family":"Geethakumari","sequence":"additional","affiliation":[{"name":"Department of Medicine Harold C. Simmons Comprehensive Cancer Center UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy L.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Medicine Siteman Cancer Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Shouse","sequence":"additional","affiliation":[{"name":"Department of Medicine City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-6658","authenticated-orcid":false,"given":"Adam J.","family":"Olszewski","sequence":"additional","affiliation":[{"name":"Department of Medicine Brown University Providence  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-3457","authenticated-orcid":false,"given":"Narendranath","family":"Epperla","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Medicine Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"},{"name":"Division of Hematology and Hematologic Malignancies Huntsman Cancer Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/aol\u201020\u201028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.08.025"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001620\u20102"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27773"},{"issue":"4","key":"e_1_2_11_6_1","first-page":"206","article-title":"Current Treatments in Marginal Zone Lymphoma","volume":"36","author":"Alderuccio J. 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