{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:18:05Z","timestamp":1791980285059,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Chronic myeloid leukemia (CML) patients who have experienced failure and\/or intolerance to multiple lines of treatment have limited therapeutic possibilities. Asciminib is a first\u2010in\u2010class tyrosine kinase inhibitor (TKI) that inhibits the ABL Myristoyl Pocket (STAMP or Specifically Targeting the ABL Myristoyl Pocket) within the\n                      <jats:italic>BCR::ABL1<\/jats:italic>\n                      oncoprotein. This retrospective Italian analysis reports the efficacy and safety outcomes of asciminib in treating 77 CML patients in chronic phase (CML\u2010CP) within a compassionate use setting. Patients were heavily pretreated with a median of 3 TKIs (55.8% had prior ponatinib exposure). Overall, 57.1% and 42.9% patients switched to asciminib because of resistance and intolerance, respectively. Asciminib maintained or improved molecular responses (MRs) in most patients: as best response, 41 patients (53%) achieved a MR3 or better, with 25 patients (32.5%) reaching deep molecular response (DMR). Greater percentages of intolerant patients achieved MR compared with resistant patients, although the probability of reaching at least a MR3 was not significant between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.116). Patients with the T315I mutation responded to asciminib, while ponatinib pre\u2010treated patients showed lower MR improvements compared to na\u00efve patients and had a lower probability to reach a MR3 versus na\u00efve patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0262). These results highlight asciminib remarkable tolerability and efficacy in real\u2010world CML\u2010CP patient population, including heavily pretreated patients, those intolerant and resistant to previous TKIs, and presenting several comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>The identification code for the MAP is CABL001AIT01M.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hon.70101","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T17:09:32Z","timestamp":1746810572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Real\u2010World Efficacy Profile of Compassionate Use of Asciminib in an Italian, Multi\u2010Resistant Chronic\u2010Phase Chronic Myeloid Leukemia (CML\u2010CP) Patient Population"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-6162","authenticated-orcid":false,"given":"Massimo","family":"Breccia","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Translational and Precision Medicine Azienda Policlinico Umberto I Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella Russo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Hematology and Transplantation Unit University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Giai","sequence":"additional","affiliation":[{"name":"Division of Haematology A.O.U. 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