{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:57Z","timestamp":1772118657620,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The characteristics at diagnosis and clinical course of primary extranodal follicular lymphoma (EFL) have not been extensively described. The International Extranodal Lymphoma Study Group (IELSG) conducted an international retrospective survey aimed to describe the clinical features at diagnosis and the outcomes of FL cases with a clinically dominant extranodal component. The dataset included 605 pathologically reviewed cases from 19 different countries, and their outcomes were compared to those of nodal follicular lymphomas. The two most common presentation sites for EFL were the skin (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0334) and the gastrointestinal tract (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a072), with 22 cases having primary duodenal localization. These subsets exhibited unique features at diagnosis and significantly different overall survival (OS) patterns. After a median follow\u2010up of 5.5\u00a0years, primary cutaneous lymphomas showed a superior outcome [10\u2010year OS: 89% (95% CI, 83%\u201393%)], while primary gastrointestinal lymphomas had an intermediate outcome [10\u2010year OS: 79% (95% CI, 59%\u201390%)]. Among the gastrointestinal lymphomas, primary duodenal lymphomas tended toward the best outcome [10\u2010year OS: 95% (95% CI, 69%\u201399%)]. Other primary extranodal sites had inferior outcomes [10\u2010year OS: 59% (95% CI, 48%\u201368%)], similar to primary nodal lymphomas [10\u2010year OS: 57% (95% CI, 49%\u201364%)]. These findings support the identification of specific primary FL localizations as distinct entities with particular clinical and biological characteristics.\n                  <\/jats:p>","DOI":"10.1002\/hon.70111","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T14:09:09Z","timestamp":1750601349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Extranodal Follicular Lymphoma: A Retrospective Survey of the International Extranodal Lymphoma Study Group (IELSG)"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-4339","authenticated-orcid":false,"given":"Annarita","family":"Conconi","sequence":"first","affiliation":[{"name":"Azienda sanitaria locale Ematologia Ospedale degli Infermi  Biella Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-7769","authenticated-orcid":false,"given":"Andrea","family":"Janikova","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-4477","authenticated-orcid":false,"given":"Barbara","family":"Vannata","sequence":"additional","affiliation":[{"name":"Haematology Department A. Tortora Hospital  Pagani Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Florencia","family":"Ram\u00edrez\u2010Ibarguen","sequence":"additional","affiliation":[{"name":"Hematology Department Instituto Nacional de Cancerologia  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Lobetti\u2010Bodoni","sequence":"additional","affiliation":[{"name":"Oncology Institute of Southern Switzerland Ente Ospedaliero Cantonale  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Belada","sequence":"additional","affiliation":[{"name":"University Hospital Hradec Kr\u00e1lov\u00e9  Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-9835","authenticated-orcid":false,"given":"Maria Cristina","family":"Pirosa","sequence":"additional","affiliation":[{"name":"Oncology Institute of Southern Switzerland Ente Ospedaliero Cantonale  Bellinzona Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mian","sequence":"additional","affiliation":[{"name":"Innovation Research and Teaching Service Hospital of Bolzano (SABES\u2010ASDAA) Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversit\u00e4t  Bolzano\u2010Bozen Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s J. M.","family":"Ferreri","sequence":"additional","affiliation":[{"name":"Lymphoma Unit IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Pete MacCallum Cancer Institute  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerassimos","family":"Pangalis","sequence":"additional","affiliation":[{"name":"Hematology Department Athens Medical Center\u2010Psychion Branch  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-3871","authenticated-orcid":false,"given":"Maria Elena","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Universidad de Chile Hospital del Salvador  Santiago 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