{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:19:50Z","timestamp":1791443990146,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900118"],"award-info":[{"award-number":["81900118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Low\u2010dose venetoclax plus strong CYP3A4 inhibitor voriconazole were commonly used for acute myeloid leukemia (AML) patients who were unfit for intensive chemotherapy in China. However, the efficacy and safety of this schedule have not been well investigated. We analyzed clinical data from 54 patients with a median age of 67\u00a0years.\u00a0Thirty patients received a standard dose of venetoclax plus azacitidine (cohort 1), whereas another 24 patients received low\u2010dose venetoclax plus voriconazole plus azacitidine (cohort 2). The composite complete remission (complete remission or complete remission with incomplete hematologic recovery; CR\/CRi) rate was 76.7% (23\/30) in cohort 1 and 87.5% (21\/24) in cohort 2 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.483). At a median follow\u2010up of 16\u00a0months, the median progression\u2010free survival was 12\u00a0months in cohort 1 and 18\u00a0months in cohort 2 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.241). The median overall survival was 14\u00a0months in cohort 1 and 19\u00a0months in cohort 2 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.453). Key adverse events included cytopenia and infections. Grade 3 or higher infections occurred in 36.7% of the patients in cohort 1 and 20.8% of those in cohort 2. In conclusion, this study demonstrated the safety and effectiveness of the combination of low\u2010dose venetoclax and voriconazole in unfit AML.\n                  <\/jats:p>","DOI":"10.1002\/hon.70113","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:29:04Z","timestamp":1751070544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Efficacy of Low\u2010Dose Venetoclax Plus Voriconazole in Patients With Acute Myeloid Leukemia Unfit for Intensive Chemotherapy"],"prefix":"10.1002","volume":"43","author":[{"given":"Xinyao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danchen","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Anhui Medical University  Hefei 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