{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:42Z","timestamp":1772118582828,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary large B\u2010cell lymphoma of immune\u2010privileged sites (IP\u2010LBCL), a recently defined entity in WHO\u2010HAEM5, includes primary diffuse large B\u2010cell lymphoma (DLBCL) occurring in immune\u2010privileged areas like the central nervous system (PCNS\u2010LBCL), vitreoretinal system (PVR\u2010LBCL), and testis (PT\u2010LBCL) in immunocompetent patients. This study aimed to identify prognostic factors and create a predictive model for IP\u2010LBCL. We analyzed 213 newly diagnosed IP\u2010LBCL patients from April 2006 to April 2023. A nomogram and prognostic index, IPLBCL\u2010PI, were developed based on elevated LDH, ECOG \u2265 2, and PCNS\u2010LBCL subtype as independent risk factors for poorer PFS. IPLBCL\u2010PI categorized patients into four risk groups: low, low\u2010intermediate, intermediate\u2010high, and high. The model effectively predicted both PFS and OS in the training cohort and was validated in two external centers. Subgroup analyses showed that IPLBCL\u2010PI outperformed the Nottingham\/Barcelona (NB) and Memorial Sloan Kettering Cancer Center (MSKCC) models in PCNS\u2010LBCL and was comparable to the International Prognostic Index (IPI) in PT\u2010LBCL. IPLBCL\u2010PI is the first prognostic model for IP\u2010LBCL, offering risk stratification and aiding clinical decision\u2010making for this rare entity.<\/jats:p>","DOI":"10.1002\/hon.70115","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:50:30Z","timestamp":1752130230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Prognostic Score for Disease Progression and Mortality in Patients With Newly Diagnosed Primary Large B\u2010Cell Lymphoma of Immune\u2010Privileged Sites"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-0847","authenticated-orcid":false,"given":"Ganggang","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine\/Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin CN"},{"name":"Cancer Center Shanxi Bethune Hospital Shanxi Academy of Medical Science Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-0079","authenticated-orcid":false,"given":"Jiesong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine\/Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin CN"},{"name":"Department of Lymphoma &amp; Head and Neck Oncology College of Clinical Medicine for Oncology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine\/Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin CN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine\/Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key 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