{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:17:56Z","timestamp":1784074676251,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Despite allo\u2010HSCT being the primary curative treatment for high\u2010risk AML, relapse\u2010free survival (RFS) remains suboptimal due to high relapse incidence. Our research focuses on optimizing the conditioning regimen by incorporating Mitoxantrone Hydrochloride Liposome (Lipo\u2010MIT), a novel nano\u2010formulation with enhanced pharmacokinetic properties and demonstrated anti\u2010leukemic efficacy. Preclinical studies have shown that Lipo\u2010MIT significantly improves survival outcomes compared to conventional mitoxantrone, and our study aims to translate these findings into clinical practice. In this study, we present the results of a Lipo\u2010MIT as part of the conditioning regimen for high\u2010risk AML patients undergoing allo\u2010HSCT. Our findings highlight the potential of Lipo\u2010MIT to improve RFS, while also providing insights into patient selection and the refinement of Lipo\u2010MIT\u2010based conditioning strategies. We believe this work contributes valuable knowledge to the field and has the potential to impact clinical practice.<\/jats:p>","DOI":"10.1002\/hon.70116","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:54:59Z","timestamp":1751594099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Efficacy and Safety of the Addition of Mitoxantrone Hydrochloride Liposome in Conditioning Regimen for High\u2010Risk Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"43","author":[{"given":"Xiaoyu","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiming","family":"Pang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhou","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhe","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-3686","authenticated-orcid":false,"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-5518","authenticated-orcid":false,"given":"Erlie","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Haihe Laboratory of Cell Ecosystem National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.12659\/aot.915381"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.03011"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2865"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2021_210426n573"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c05194"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010014\u20102523\u20108"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010021\u201001182\u20107"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26800"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.07.021"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2016.04.014"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T05:23:11Z","timestamp":1756185791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.70116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/hon.70116"],"URL":"https:\/\/doi.org\/10.1002\/hon.70116","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.70116\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70116\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70116\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70116\/v2\/response1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70116"}}