{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:54:36Z","timestamp":1793318076870,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Our study aimed to assess the prognostic significance of the interim National Comprehensive Cancer Network International Prognostic Index and PET\u2010CT\u2010related parameters for predicting patient outcomes and achieving precise risk stratification for diffuse large B\u2010cell lymphoma (DLBCL) patients. We retrospectively analyzed the clinicopathological and PET\u2010CT data of 498 patients diagnosed with DLBCL across three medical centers in China. 418 patients were eligible for subsequent analysis after excluding those with incomplete data and 70% of which were randomly selected as the discovery cohort, whereas the remaining 30% constituted the validation cohort. The impact of candidate factors on survival was assessed via univariate and multivariate Cox proportional hazards models. The area under the curve AUC and C\u2010index were calculated to assess the predictive performance of models. Univariate and multivariate Cox regression analyses identified changes in total lesion glycolysis (\u0394TLG), iNCCN\u2010IPI, interim abdominal residual disease (iARD) status, and changes in the maximum standardized uptake value (\u0394SUVmax) as independent prognostic factors. Leveraging the outcomes of the multivariate analysis, we constructed the iPET\u2010NCCN\u2010IPI prognostic model and categorized DLBCL patients into two separate prognostic risk groups based on their computed Risk Scores (\n                    <jats:italic>RS\u00a0=\u00a00.90\u00d7iNCCN\u2010IPI + 1.41\u00d7\u0394TLG + 0.79\u00d7\u0394SUVmax + 0.83\u00d7iARD<\/jats:italic>\n                    ). The predictive performance of the model was validated by calculating the area under the receiver operating characteristic curve and the C\u2010index. Notably, compared with other models, the iPET\u2010NCCN\u2010IPI demonstrated superior prognostic capability. In conclusion, our study indicates that the iPET\u2010NCCN\u2010IPI stratifies DLBCL patients into two distinct prognostic risk groups and surpasses other models in prognostic predictive ability.\n                  <\/jats:p>","DOI":"10.1002\/hon.70118","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T01:20:16Z","timestamp":1751937616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk Stratification for Diffuse Large B\u2010Cell Lymphoma by Integrating Interim\n                    <sup>18<\/sup>\n                    F\u2010FDG PET\u2010CT Analysis and the NCCN\u2010IPI: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-0079","authenticated-orcid":false,"given":"Jiesong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"},{"name":"Department of Lymphoma &amp; Head and Neck Oncology College of Clinical Medicine for Oncology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Kindstar Biotech  Wuhan China"},{"name":"Kindstar Global Precision Medicine Institute  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Center Shengli Clinical Medical College of Fujian Medical University Fujian Provincial Hospital Fuzhou University Affiliated Provincial Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghu","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudan","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzi","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchen","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pathology Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology Tianjin Medical University Cancer Institute and Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Yu","sequence":"additional","affiliation":[{"name":"Kindstar Biotech  Wuhan China"},{"name":"Kindstar Global Precision Medicine Institute  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Ye","sequence":"additional","affiliation":[{"name":"Kindstar Biotech  Wuhan China"},{"name":"Kindstar Global Precision Medicine Institute  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8558-3131","authenticated-orcid":false,"given":"Huilai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer the Sino\u2010US Center for Lymphoma and Leukemia Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1998.16.8.2780"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(08)70002\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)60313\u2010x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1986.4.2.160"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201003\u2010769620"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2022.10.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050275"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2001.19.2.414"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.54.8800"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.53.5229"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.145326"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.831848"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000002808"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000553"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010016\u20103534\u2010y"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1339877"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010018\u20104103\u20103"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.05.010"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.66.9440"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210224"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003526"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1277384"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2805"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.231621"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002729"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201009\u2010524108"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010016\u20103315\u20107"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23267"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550\u2010024\u201001074\u2010w"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.115.161745"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2284"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13361"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw419"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201001\u20100272"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn629"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.082586"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.5942"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.38.2648"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.12.027"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s218678"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010019\u201003834\u20104"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T05:23:09Z","timestamp":1756185789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.70118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/hon.70118"],"URL":"https:\/\/doi.org\/10.1002\/hon.70118","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.70118\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70118\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70118\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70118\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70118\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70118"}}