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Gain and loss\u2010of\u2010function studies were performed on lymphoblast cell lines DB and SU\u2010DHL\u20104 to investigate its function. TRIM44 overexpression significantly promoted cell proliferation and viability, whereas its silencing inhibited proliferation and induced apoptosis. TRIM44 overexpression upregulated the LC3II\/LC3\u2010I ratio and Beclin1 expression, as well as increased autophagosomes formation, suggesting autophagy activation. Notably, TRIM44 conferred chemoresistance to doxorubicin in DB cells by increasing autophagic activity. In vivo study on mice revealed that TRIM44 overexpression increased Ki67 and PCNA expression, suggesting an increased tumor growth. Our previous work revealed that miR\u2010665 is a tumor suppressor in DLBCL. The results of miRNA pull\u2010down and luciferase reporter assay indicated that TRIM44 was a direct target of miR\u2010665. In conclusion, TRIM44 promoted DLBCL progression by increasing autophagy\u2010mediated chemoresistance, revealing the involvement of miR\u2010665\/TRIM44 axis.<\/jats:p>","DOI":"10.1002\/hon.70119","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T06:59:59Z","timestamp":1752821999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deubiquitinase TRIM44 Promotes Autophagy\u2010Mediated Chemoresistance in Diffuse Large B Cell Lymphoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7349-9257","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated Taian City Central Hospital of Qingdao University  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banban","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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