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However, a subset of FL patients experiences early relapse and progression within 24\u00a0months (POD24) after first line treatment, which is a sign of poor prognosis. Current guidelines recommend various second\u2010line treatments, but there is no consensus on an optimal treatment sequence for relapsed\/refractory (r\/r) FL. Moreover, despite available treatments, reduced survival after second\u2010line therapies and diminishing responses with each relapse highlight the unmet need for more effective options. Chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy has emerged as a promising treatment for r\/r FL beyond 2\n                    <jats:sup>nd<\/jats:sup>\n                    line therapy, with three FDA\/EMA\u2010approved therapies (axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel) showing high efficacy and manageable side effects. However, challenges remain in determining which patients will benefit most from CAR\u2010T, especially given its high cost, safety concerns, and logistical barriers. A consensus study was conducted to guide CAR\u2010T patient selection and treatment sequencing for patients in 3rd line or beyond. Key findings suggest that younger patients, those with high disease burden or poor first\u2010line responses, should be prioritized for CAR\u2010T. Additionally, CAR\u2010T is recommended as a third\u2010line option for patients with POD24, double refractoriness (failure to respond to two subsequent lines of immunochemotherapy), or early autologous stem cell transplant failure. The study underscores the importance of early assessment of treatment response, careful second\u2010line therapy selection, and patient adherence to ensure optimal outcomes. The results, based on expert consensus, support CAR\u2010T therapy as a viable option for r\/r FL patients, offering hope for durable remissions in this challenging cohort.\n                  <\/jats:p>","DOI":"10.1002\/hon.70125","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:59:57Z","timestamp":1758639597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A SWOT\u2010Consensus for CAR\u2010T in Follicular Lymphoma: Fine Tuning of Patient Journey and Selection"],"prefix":"10.1002","volume":"43","author":[{"given":"Monia","family":"Marchetti","sequence":"first","affiliation":[{"name":"SCDU Ematologia Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo  Alessandria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Corradini","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia Fondazione IRCCS Istituto Nazionale 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