{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:15:44Z","timestamp":1789132544755,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Late cardiac toxicity after radiation therapy and\/or systemic therapy with anthracyclines for lymphomas is a serious concern. To estimate the risks with different treatment combinations, reliable estimates of the dose\u2010response relationships are needed. We performed a literature\u2010based regression analysis of long\u2010term cardiac events after lymphoma treatment. The objective was to identify dose\u2010response relationships for anthracycline and radiotherapy regarding congestive heart failure (CHF), ischemic heart disease (IHD), and valvular heart disease (VHD). We included papers published January 2000\u2010December 2022 with data on long term cardiac outcomes in lymphoma patients, radiation doses to the heart, and anthracycline doses. Papers without dose\/response information were excluded. We identified six eligible papers including 22,916 patients. The excess relative risk (ERR) of CHF for anthracyclines per 100\u00a0mg\/m2 (corresponding to 2 cycles of ABVD or CHOP chemotherapy) was 92% (CI: 74%\u2013101%), and for radiotherapy per Gray (Gy) of mean heart dose it was 6.1% (CI: 4.4%\u20137.6%). Corresponding numbers for the other endpoints were: IHD: No effect of anthracyclines, ERR\u00a0=\u00a04.4%\/Gy (CI: 2.7%\u20136.1%) and VHD: ERR\u00a0=\u00a025%\/100\u00a0mg\/m2 (CI: 13%\u201337%) and ERR\u00a0=\u00a010%\/Gy (CI: 6%\u201313%). Data agree with a linear no threshold dose\u2010response relationship for related endpoints, that is, there are no \u201csafe\u201d lower doses of either anthracyclines or radiotherapy. Late cardiac toxicity risks for all three endpoints can be assessed in each patient by a combined estimate from the cumulative doses of anthracyclines and radiation to the heart. This estimate can guide future treatment allocation in lymphoma patients.<\/jats:p>","DOI":"10.1002\/hon.70134","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:04:20Z","timestamp":1756375460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Late Cardiac Toxicity After Anthracyclines and Radiotherapy for Lymphoma\u2014A Regression Analysis of Dose\u2010Response"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-1007","authenticated-orcid":false,"given":"Lotte","family":"Nyg\u00e5rd","sequence":"first","affiliation":[{"name":"Department of Oncology Section of Radiotherapy Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Richter","family":"Vogelius","sequence":"additional","affiliation":[{"name":"Department of Oncology Section of Radiotherapy Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus F.","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Bentzen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health School of Medicine University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-2190","authenticated-orcid":false,"given":"Lena","family":"Specht","sequence":"additional","affiliation":[{"name":"Department of Oncology Section of Radiotherapy Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15603"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26230"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.00408"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.02613"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(20)30031\u20104"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(15)00153\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.1180"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.63.4444"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201009\u2010740332"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224519"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1209825"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010015\u20100863\u2010y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.03.019"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt156"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186x.2014.932435"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210469"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2007.02.005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ppo.0000000000000332"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.10.028"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210303"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.11.028"},{"key":"e_1_2_10_25_1","unstructured":"\u201cDanish Heart Association.\u201d [Internet] https:\/\/www.cardio.dk\/."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802140873"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.20.2267"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)30215\u20107"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.01.021"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601904"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.74.8673"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26367"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.60.8125"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201007\u2010034405"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4606"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201006\u2010291328"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.33.4730"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.03.026"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.02.060"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.03.045"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2023.03.005"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15353"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201003\u2010837633"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.54669"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11407"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.12.121"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.136093"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22364"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2019.08.001"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.6634"},{"key":"e_1_2_10_51_1","article-title":"Cardiac Dose\u2010Volume Analysis of 9,411 Patients With Registry Data for Cardiovascular Disease and Overall Survival","author":"Forbes N.","year":"2024","journal-title":"Oncology"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:52:10Z","timestamp":1759549930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.70134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/hon.70134"],"URL":"https:\/\/doi.org\/10.1002\/hon.70134","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.70134\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70134\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70134\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70134\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70134\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70134\/v2\/review1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"2025-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70134"}}