{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:45:16Z","timestamp":1791431116531,"version":"4.3.3"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Primary central nervous system lymphomas (PCNSL) are rare malignancies with poor survival outcomes. The IELSG32 trial demonstrated efficacy of MATRix chemoimmunotherapy followed by autologous stem cell transplantation (auto\u2010SCT) in PCNSL patients aged \u2264\u00a070\u00a0years with a performance status (PS) ECOG \u2264\u00a03. However, long\u2010term real\u2010world results of MATRix\/auto\u2010SCT therapy remain limited. This analysis, with a median follow\u2010up of 52\u00a0months, aimed to evaluate the outcomes of MATRix\u2010treated PCNSL patients in clinical practice. From 2015 to 2022, 280 PCNSL patients who received systemic therapy were identified in the NiHiL project (NCT03199066). Eighty\u2010eight individuals treated with MATRix entered the analysis. Endpoints included efficacy and safety of induction and consolidation therapy. Seventy\u2010eight patients who met key IELSG32 inclusion criteria (age \u2264\u00a065\u00a0years and PS ECOG \u2264\u00a03, or age 66\u201370\u00a0years and PS ECOG \u2264\u00a02) achieved an overall response rate of 82% (complete remission rate 58%) following MATRix regimen. After median follow\u2010up of 52\u00a0months, 4\u2010year progression\u2010free survival and overall survival (OS) rates were 53% and 55%, respectively. Forty\u2010six (59%) patients completed MATRix treatment, and 32 (41%) discontinued induction therapy (15 toxicity, 11 infections, 5 progressive diseases, 1 refusal). The treatment\u2010related mortality was 8%. Among 67 patients with responsive\/stable disease, 50 underwent consolidation with whole\u2010brain radiotherapy (WBRT,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013) or auto\u2010SCT (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037). No significant survival differences were observed between WBRT and auto\u2010SCT (4\u2010year OS 84% vs. 74%, HR 0.61, 95% CI 0.16\u20132.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.467). Long\u2010term real\u2010world outcomes of MATRix\/auto\u2010SCT therapy are comparable to IELSG32, supporting its use in younger, fit PCNSL patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>The data in this analysis were collected in the observational Czech non\u2010Hodgkin lymphoma registry \u201cNiHiL\u201d (NCT03199066)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hon.70142","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:04:44Z","timestamp":1760796284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Real\u2010World Outcomes of Primary CNS Lymphoma Patients Treated With MATRix Regimen Are Similar to IELSG32 Trial Results"],"prefix":"10.1002","volume":"43","author":[{"given":"Prokop","family":"Vodicka","sequence":"first","affiliation":[{"name":"First Department of Medicine First Faculty of Medicine Charles University General Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Janikova","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Faculty of Medicine Masaryk University and University Hospital  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Belada","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine\u2014Hematology Faculty of Medicine Charles University and University Hospital Hradec Kralove  Hradec Kr\u00e1lov\u00e9 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Hanackova","sequence":"additional","affiliation":[{"name":"Department of Haemato\u2010Oncology Faculty of Medicine and Dentistry Palacky University and University Hospital  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Mocikova","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Faculty of Medicine Charles University and University Hospital Kralovske Vinohrady  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Duras","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical Faculty of the Ostrava University and University Hospital  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Steinerova","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Faculty of Medicine Charles University and University Hospital Pilsen  Pilsen Czech 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