{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:52:38Z","timestamp":1780987958109,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Patients with Hodgkin lymphoma (HL) or peripheral T\u2010cell lymphoma (PTCL) who relapse after high\u2010dose chemotherapy (HDCT) have a dismal prognosis. Brentuximab\u2010vedotin (BV) is a CD30\u2010targeting antibody\u2010drug\u2010conjugate (ADC) used in first\u2010line\u2010, salvage\u2010, and maintenance\u2010therapy of HL, as well as first\u2010line\u2010 and salvage\u2010therapy of PTCL. In phase I of this trial, we could show that BV can safely be added to BeEAM\u2010HDCT (bendamustine, etoposide, cytarabine and melphalan). Here, we report the randomized phase II part of the trial comparing BV\u2010BeEAM to BeEAM alone (ClinicalTrials.gov: NCT03187210). Primary endpoint was 1\u2010year disease\u2010free survival. Inclusion of 42 patients was planned but the study was terminated early, after a futility analysis showed lack of benefit. Twenty\u2010five patients (HL: 11, PTCL: 14) who were planned to undergo HDCT were included. Median age was 60\u00a0years. Patients had a median of two prior therapies, and 11 were previously exposed to BV. Patients in the standard\u2010arm had higher disease stage and (PTCL only) higher IPI. Duration of hospitalization, recovery of neutrophils\/platelets, and infections were not significantly different between arms. No treatment related death occurred. However, two patients in the BV\u2010arm developed grade 3 pneumonitis. After 22\u00a0months median follow\u2010up, overall response\u2010rate, complete remission\u2010rate, disease\u2010free survival and overall survival did not differ between groups. Pre\u2010planned subgroup\u2010analyses (HL\u2010only, PTCL\u2010only, only those achieving CR) did not show benefit in any subgroup. In conclusion, adding BV to BeEAM does not improve outcomes after HDCT, and may increase pulmonary toxicity. Frequent prior exposure to BV may have limited the potential benefit of the combination.<\/jats:p>","DOI":"10.1002\/hon.70143","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:19:24Z","timestamp":1761070764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Randomized Phase II Study of Brentuximab\u2010Vedotin With High\u2010Dose Chemotherapy in CD30 Positive Lymphoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-5526","authenticated-orcid":false,"given":"Christian","family":"Rausch","sequence":"first","affiliation":[{"name":"Department of Medicine III LMU University Hospital  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Bacher","sequence":"additional","affiliation":[{"name":"Department of Hematology and Central Hematological Laboratory Inselspital University Hospital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Rabaglio","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Inselspital University Hospital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Vorburger","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Inselspital University Hospital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Klingenberg","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Inselspital University Hospital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Banz","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Daskalakis","sequence":"additional","affiliation":[{"name":"Department of Hematology and Central Hematological Laboratory Inselspital University Hospital Bern University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pabst","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Inselspital University Hospital Bern University of Bern  Bern 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