{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:57:34Z","timestamp":1773061054342,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Clonal hematopoiesis of indeterminate potential (CHIP) is a predisposing condition to lymphoma development. CHIP carrying mutations that are recurrently found in lymphomas are designated as L\u2010CHIP. We presume that bone marrow\u2010derived L\u2010CHIP populations are able to expand and manifest in peripheral lymphoid tissues, where they could hence be called\n                    <jats:italic>L\u2010CHIP tissue\u2010equivalents<\/jats:italic>\n                    . There, they may proliferate and foster unexplained follicular hyperplasias, and, thus, potentially represent an early precursor of lymphoma. Analogously, we hypothesize that certain germline\u2010derived mutations lead to lymphoproliferations (\n                    <jats:italic>germline\u2010derived lymphoproliferations<\/jats:italic>\n                    ) in otherwise healthy individuals. We collected seven exceptional cases of symptomatic nodal and extranodal lymphoid hyperplasias, which were all morphologically suspicious and displayed somatic and\/or germline\u2010derived mutations recurrently found in B\u2010cell lymphomas. One patient developed follicular lymphoma after 8\u00a0years carrying the same non\u2010productive immunoglobulin rearrangement detected in the initial biopsy. L\u2010CHIP tissue\u2010equivalents and germline\u2010derived lymphoproliferations potentially represent first steps in lymphomagenesis and knowledge about their existence might be of diagnostic utility in challenging cases of (atypical) lymphoproliferations. With histology, immunohistochemistry, and molecular testing, such lesions can be identified in situ.\n                  <\/jats:p>","DOI":"10.1002\/hon.70145","type":"journal-article","created":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:55:15Z","timestamp":1760248515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tissue\u2010Equivalents of Lymphoid Clonal Hematopoiesis of Indeterminate Potential (L\u2010CHIP) and Germline\u2010Derived Lymphoproliferations: Possible Caveats for Hematopathologists"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-1377","authenticated-orcid":false,"given":"Magdalena M.","family":"Brune","sequence":"first","affiliation":[{"name":"Institute of Medical Genetics and Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Bratic Hench","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Dirnhofer","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-3819","authenticated-orcid":false,"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Pathology University Hospital Basel  Basel 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