{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:35Z","timestamp":1786977875463,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We investigated the course of fatigue, neuropathy, psychological distress and their impact on HRQoL among diffuse large B\u2010Cell Lymphoma (DLBCL) survivors up to 13\u00a0years after diagnosis, and compared it to an age\u2010 and sex\u2010matched population. DLBCL survivors diagnosed between 2004 and 2011, who survived \u2265\u00a01\u00a0year were selected from the Netherlands Cancer Registry. Survivors completed annual questionnaires 2009\u20132019, including EORTC QLQ\u2010C30, EORTC CLL\u201017 and the Hospital Anxiety and Depression Scale. Linear mixed models were used to assess symptom trends and HRQoL associations over time. 302 survivors (response rate 84%) completed a median of three questionnaires. Fatigue improved slightly over time but neuropathy and psychological distress remained unchanged; persistent symptoms were reported by 25%, 28%, and 23% of survivors, respectively. Having\u00a0two or more comorbidities was associated with higher symptom levels (\u03b2\n                    <jats:sub>fatigue<\/jats:sub>\n                    \u00a0=\u00a07.8,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0&lt;\u00a00.001; \u03b2\n                    <jats:sub>neuropathy<\/jats:sub>\n                    \u00a0=\u00a06.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a00.003;\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>psychological distress<\/jats:sub>\n                    \u00a0=\u00a02.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value &lt;\u00a00.001). Having received seven to eight cycles of (R\u2010)CHOP14 was associated with higher neuropathy levels (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a014.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and non\u2010(R\u2010)CHOP treatments were associated to high fatigue levels (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a014.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a00.02) and psychological distress (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a04.3,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a00.01). Higher symptom levels were associated with poorer HRQoL. One in four DLBCL survivors reported persistent fatigue, neuropathy or psychological distress, negatively impacting their HRQoL. Routine symptom monitoring is essential to identify needs and guide supportive care referrals.\n                  <\/jats:p>","DOI":"10.1002\/hon.70151","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T06:43:23Z","timestamp":1762584203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fatigue, Neuropathy and Psychological Distress and Their Association With Health\u2010Related Quality of Life in Survivors of Diffuse Large B\u2010Cell Lymphoma: A Prospective Cohort Study and Comparison With a Normative Population"],"prefix":"10.1002","volume":"43","author":[{"given":"Suzanne I. M.","family":"Neppelenbroek","sequence":"first","affiliation":[{"name":"Department of Psychosocial Research Division of Psychosocial Research &amp; Epidemiology The Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afke","family":"Ekels","sequence":"additional","affiliation":[{"name":"Department of Psychosocial Research Division of Psychosocial Research &amp; Epidemiology The Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Jos\u00e9","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Centers Location University of Amsterdam Cancer Center Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4512-7019","authenticated-orcid":false,"given":"Djamila E.","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Hematology Jeroen Bosch Ziekenhuis  Den Bosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noortje","family":"Thielen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Diakonessenhuis  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonneke V.","family":"van de Poll\u2010Franse","sequence":"additional","affiliation":[{"name":"Department of Psychosocial Research Division of Psychosocial Research &amp; Epidemiology The Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Oerlemans","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra2027612"},{"key":"e_1_2_9_3_1","unstructured":"IKNL. 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