{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:57:38Z","timestamp":1773061058132,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The introduction of pediatric\u2010inspired chemotherapy protocols for acute lymphoblastic leukemia (ALL) in the setting of adult patients affected by lymphoblastic lymphoma (LL) has improved the results in terms of outcomes. Within the Campus ALL network, we retrospectively collected data on 50 LL\u2010patients from 23 hematology centers in Italy treated according to the GIMEMA LAL1913 protocol, with the aim of confirming the ALL results and of testing the effectiveness of an approach based on higher cumulative doses of the non\u2010myelosuppressive components such as steroids and pegylated asparaginase, in addition to earlier and more intensive central nervous system prophylaxis. After cycle 3 (high dose methotrexate and cytarabine, C3), the cumulative incidence (CI) of PET\u2010based complete response (CR) was of 83% (median time to response from protocol start: 3.7\u00a0months; CI95%: 3.1\u20134.2). With a median follow\u2010up of 27.5\u00a0months, the 2\u2010year overall survival (OS), disease free survival (DFS) ed event free survival rates were of 77%, 76% and 69%, respectively. The 2\u2010year CI of relapse was of 26%. Multivariable analysis identified ECOG \u2265 2 as an independent prognostic factor for OS (HR\u00a0=\u00a03.279; CI95% 1.035\u201310.389,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.044) and DFS (HR\u00a0=\u00a013.00, ICI95%: 3.383\u201357.909,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), respectively. No significant impact was observed for pegylated asparaginase dose (reduced and\/or omitted versus (vs.) full doses), age (\u2265 55 vs.\u00a0&lt;\u00a055), stage (0\u2013I vs. II\u2013IV), CD1a (negativity vs. other than CD1a negativity), bone marrow involvement (absent vs.\u00a0\u2264\u00a020%), or allotransplantation. The results of this study show the appropriateness of the LAL1913 protocol for the management of LL patients. Survival outcomes reflect those expected, although this drug combination was never tested before in a real\u2010life setting. Taken together, these results suggest that LAL1913 might be considered as a reference protocol for the frontline treatment of adult LL patients.\n                  <\/jats:p>","DOI":"10.1002\/hon.70153","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:41:31Z","timestamp":1763001691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcome of Adult Lymphoblastic Lymphoma Patients Treated in the Real Life According to the Gimema LAL1913 Protocol: A Campus ALL Multicenter Study"],"prefix":"10.1002","volume":"43","author":[{"given":"M.","family":"Delia","sequence":"first","affiliation":[{"name":"U.O.C. Ematologia con Trapianto Azienda Ospedaliero\u2010Universitaria\u2010Consorziale Policlinico  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Lazzarotto","sequence":"additional","affiliation":[{"name":"Centro Trapianti e Terapie Cellulari Clinica Ematologica Azienda Sanitaria Universitaria Friuli Centrale  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Imbergamo","sequence":"additional","affiliation":[{"name":"Dipartimento Strutturale Aziendale Medicina Universit\u00e0 di Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mosna","sequence":"additional","affiliation":[{"name":"U.O. di Ematologia e Trapianto di Midollo Osseo Ospedale di Bolzano Universit\u00e0 Medica Paracelsus  Bolzano Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Papayannidis","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pasciolla","sequence":"additional","affiliation":[{"name":"U.O. di Ematologia IRCCS Istituto Tumori Giovanni Paolo II  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mul\u00e8","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ad indirizzo Oncologico A.O. Ospedali Riuniti Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Fracchiolla","sequence":"additional","affiliation":[{"name":"U.O. Ematologia IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Leoncin","sequence":"additional","affiliation":[{"name":"UOC Ematologia Azienda Ulss3 Serenissima Ospedale dell\u2019Angelo  Venezia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. I.","family":"Del Principe","sequence":"additional","affiliation":[{"name":"Dipartimento di Biomedicina e Prevenzione Universit\u00e0 di RomaTor Vergata  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Ematologia Ospedale San Gerardo ATS Brianza  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Olivi","sequence":"additional","affiliation":[{"name":"U.O.C Ematologia A.O.U. Citt\u00e0 della Salute e della Scienza  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Guolo","sequence":"additional","affiliation":[{"name":"U.O. Ematologia e Terapie Cellulari IRCCS Ospedale Policlinico San Martino  Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lunghi","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia Azienda Ospedaliera Universitaria Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"De Gobbi","sequence":"additional","affiliation":[{"name":"A.O.U. San Luigi Gonzaga SCDU Medicina Interna ad indirizzo ematologico  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-8616","authenticated-orcid":false,"given":"F.","family":"Lussana","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia ASST Ospedale Papa Giovanni XXIII Bergamo \u2010 Dipartimento di Oncologia\u2010Ematologia \u2010 Universit\u00e0 degli Studi di Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Santoro","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia e Trapianto di Midollo Osseo  Avellino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Aprile","sequence":"additional","affiliation":[{"name":"U.O. Ematologia Ospedale San Giuseppe Moscati  Taranto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zappasodi","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ciccone","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia Arcispedale Sant\u2019Anna  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Giglio","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia e Trapianto di Midollo Osseo IRCCS Ospedale San Raffaele  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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