{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:54:41Z","timestamp":1774497281811,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lymphomas are common cancers affecting the lymphatic system. Chemotherapy is a standard treatment, yet its impact on patient's physical capacity remains understudied. This study aimed to evaluate changes in body composition, muscle strength, and physical performance in patients diagnosed with lymphoma undergoing chemotherapy and to explore the potential association between muscle function and treatment tolerability. This single\u2010center prospective cohort study included participants aged \u2265\u00a018\u00a0years scheduled for first\u2010line anthracycline\u2010based chemotherapy for aggressive lymphoma. Patients were recruited and tested before treatment and after 6\u00a0months. Body composition (DXA), hand\u2010grip strength, 30\u00a0s Sit\u2010To\u2010Stand test, 10\u2010m gait speed and Quality of Life (EORTC\u2010QLQ\u2010C30) were assessed. Low muscle strength, lean mass and gait speed were defined according to the European Working Group on Sarcopenia in Older People (EWGSOP2). Fifty\u2010eight patients (42 males) with a median age of 62\u00a0years (range 18\u201387) completed both test points and were included in the analysis. From baseline to follow\u2010up, total lean mass decreased by 1.70\u00a0kg (95% CI \u22122.55 to \u22120.85,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0002), body fat percentage increased by 2.3% (95% CI 1.19 to 3.41,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0001), handgrip strength decreased by 1.93\u00a0kg (95% CI \u22123.15 to \u22120.71,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002), whereas Sit\u2010To\u2010Stand performance increased by 1.4 repetitions (95% CI 0.15 to 2.69,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.03). No changes were observed in appendicular lean mass, body weight, or gait speed. Further, there was no association between changes in muscle function and treatment tolerability. Significant declines in total lean body mass and muscle strength were observed from the start of chemotherapy to 6\u00a0months post treatment. These findings underscore the importance of routine muscle function screening and rehabilitation during and after chemotherapy for patients with lymphoma.\n                  <\/jats:p>","DOI":"10.1002\/hon.70154","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:56:21Z","timestamp":1762282581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes in Lean Muscle Mass, Muscle Strength, and Physical Performance Following First\u2010Line Chemotherapy in Patients With Lymphoma"],"prefix":"10.1002","volume":"43","author":[{"given":"Charlotte N\u00f8rregaard","family":"Gr\u00f8nset","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy Centre of Head and Orthopedics Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Jarden","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer and Organ Diseases Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy Centre of Head and Orthopedics Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Tolver","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Statistics and Data Analysis  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-6508","authenticated-orcid":false,"given":"Charlotte","family":"Suetta","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Geriatric Research Unit Copenhagen University Hospital Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Hematology Center for Cancer and Organ Diseases Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001620\u20102"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_4_1","unstructured":"HowladerN. 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