{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:48:32Z","timestamp":1789213712901,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The combination of tafasitamab and lenalidomide (tafa\u2010lena) has demonstrated efficacy in relapsed\/refractory diffuse large B\u2010cell lymphoma (R\/R DLBCL), as evidenced by the L\u2010MIND study. To investigate the therapeutic potential and safety profile of tafa\u2010lena in real\u2010life, we conducted a national multicentric retrospective study. Eighty\u2010three patients with median age of 74\u00a0years were enrolled. The 49.4% of patients had a disease refractory to the first line therapy while 63.9% were refractory to the most recent one. The best overall response rate was 47% (28.9% complete remission). With a median follow\u2010up of 16\u00a0months, the median overall survival (OS) was 8.6\u00a0months and the median progression\u2010free survival (PFS) was 4.5\u00a0months. Disease\u2010free survival and median duration of response were reached at 52.8 and at 52.1\u00a0months, respectively. Compared to refractory disease (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a053, 63.9%), relapsed disease (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a026, 31.3%) was associated with better outcome in term of PFS (median 2.8 vs. 12.4\u00a0months) and OS (median 5.4\u00a0months vs. not reached). Neutropenia (52.5%) was the most common adverse events, predominantly related to lenalidomide. Our findings align with other real\u2010world studies, supporting the regimen as effective and safe, and highlighting that one third of patients experiencing long\u2010lasting responses even with dose reduction.\n                  <\/jats:p>","DOI":"10.1002\/hon.70167","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:22:01Z","timestamp":1768386121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["TALOs, Fill the Gap: Tafasitamab and Lenalidomide in Diffuse Large B\u2010Cell Lymphoma in the Real\u2010Life Patient Journey"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-4626","authenticated-orcid":false,"given":"Lisa","family":"Argnani","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche (DIMEC) Alma Mater Studiorum Universit\u00e0 of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"IRCCS IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-5313","authenticated-orcid":false,"given":"Ombretta","family":"Annibali","sequence":"additional","affiliation":[{"name":"UOS DH Ematologico Area Ematologia Trapianto Cellule Staminali Fondazione Policlinico Universitario Campus Bio\u2010Medico  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Angelillo","sequence":"additional","affiliation":[{"name":"Lymphoma Unit Hematology and Bone Marrow Transplantation Unit Department of OncoHematology IRCCS San Raffaele Scientific Institute  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Amaducci","sequence":"additional","affiliation":[{"name":"A.O. Citta della Salute e della Scienza  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Ospedale Policlinico San Martino\u2014IRCCS  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaminia","family":"Bellisario","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bernardelli","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bruna","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Translational Medicine Universit\u00e0 del Piemonte Orientale and Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catello","family":"Califano","sequence":"additional","affiliation":[{"name":"ASL Salerno  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusy","family":"Cetani","sequence":"additional","affiliation":[{"name":"AO Sant'Anna e San Sebastiano di Caserta  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Daghia","sequence":"additional","affiliation":[{"name":"U.O. di Ematologia \u2010 Dipartimento di Oncologia e Medicine Specialistiche Azienda Ospedaliero Universitaria di Ferrara Cona  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-8140","authenticated-orcid":false,"given":"Enrico","family":"Derenzini","sequence":"additional","affiliation":[{"name":"Clinical Haemato\u2010Oncology Division IEO European Institute of Oncology  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Frolli","sequence":"additional","affiliation":[{"name":"SCDU Ematologia AO Mauriziano  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Gaudio","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit AOU Consorziale Policlinico  Bari Italy"},{"name":"Department of Medicine and Surgery LUM University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2001-8000","authenticated-orcid":false,"given":"Valerio","family":"Guarente","sequence":"additional","affiliation":[{"name":"UOC Oncoematologia Ospedale \u201cS. 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