{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:11:10Z","timestamp":1775646670608,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    CD20\u2010negative large B\u2010cell lymphomas exhibit aggressive behavior and are ineligible for rituximab\u2010containing therapy. To identify antigens targeted by treatment, we analyzed CD79B and CD19 expression in 108 samples from 75 patients with CD20\u2010negative large B\u2010cell lymphomas using H\u2010score. Diffuse\u2010strong (H\u2010score 300) CD79B and CD19 expression was observed in 51% and 57% of samples, and low\/negative (H\u2010score \u2264 100) in 35% and 30%, respectively. CD79B expression was significantly lower in de novo CD20\u2010negative diffuse large B\u2010cell lymphoma (DLBCL) than in CD20\u2010negative DLBCL changed from CD20\u2010positive DLBCL after rituximab\u2010containing therapy and in CD20\u2010negative DLBCL transformed from CD20\u2010positive low\u2010grade B\u2010cell lymphoma after rituximab\u2010containing therapy (H\u2010score \u2264 100 in 79% vs. 27% vs. 10%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). CD19 expression was lower in de novo CD20\u2010negative DLBCL than in transformed DLBCL (H\u2010score \u2264 100 in 43% vs. 3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.006). Of 12 patients with plasmablastic lymphoma, CD79B and CD19 were negative in 83% and 66% of cases, respectively. Among 46 CD20\u2010negative large B\u2010cell lymphomas with low CD79B and\/or CD19 expression, the tumor proportion score for programmed death\u2010ligand 1 was positive (\u2265 1%) in 33% of cases. The combined positive score for programmed death\u2010ligand 1 was positive in 52% of programmed death\u2010ligand 1 tumor proportion score\u2010negative samples. In conclusion, CD79B and CD19 were variably expressed in CD20\u2010negative large B\u2010cell lymphomas, but lower in de novo DLBCL, and especially in plasmablastic lymphoma. Programmed cell death protein 1\/programmed death\u2010ligand one inhibitors may represent a treatment option.\n                  <\/jats:p>","DOI":"10.1002\/hon.70173","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:19:51Z","timestamp":1771053591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Expression of CD79B, CD19, and PD\u2010L1 in de Novo and Transformed CD20\u2010Negative Large B\u2010Cell Lymphomas"],"prefix":"10.1002","volume":"44","author":[{"given":"Yuto","family":"Kaimi","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"},{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Pathology and Clinical Laboratory JR Tokyo General Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Ochi","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Makita","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2423-9978","authenticated-orcid":false,"given":"Suguru","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4679-0656","authenticated-orcid":false,"given":"Wataru","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-8057","authenticated-orcid":false,"given":"Koji","family":"Izutsu","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-559X","authenticated-orcid":false,"given":"Yasushi","family":"Yatabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"},{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko Miyagi","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010015\u20104205\u20105"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010019\u201003853\u20101"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000753"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000234"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010012\u20101407\u20104"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010025\u201006187\u20103"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1307242"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022019340"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.18502\/ijhoscr.v13i2.691"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008790"},{"key":"e_1_2_15_12_1","volume-title":"Haematolymphoid Tumours Part B. 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