{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:05:00Z","timestamp":1793639100272,"version":"4.5.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Measurable residual disease (MRD) status in chronic lymphocytic leukemia (CLL) patients treated with venetoclax is a predictive factor of outcome in clinical trials. This multicenter prospective study was aimed to show the feasibility of MRD assessment in the real\u2010life setting and to confirm the results of clinical trials. Forty\u2010four patients were enrolled: 43% had 17p deleted and\/or TP53 mutated (del17p\/TP53mut), 62% had complex karyotype, and 65% of patients were previously treated with B\u2010cell receptor inhibitor (BCRi). MRD was evaluated by 8\u2010color flow cytometry (FC) on peripheral blood (PB) every 3\u00a0months from therapy start and samples with 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    CLL cells were considered as undetectable (uMRD). PB\u2010uMRD patients were evaluated on bone marrow (BM). In 23 patients venetoclax was combined with Rituximab (VR). Median follow\u2010up was 39.47\u00a0months (range 31.02\u201343.32). Median number of PB samples for each patients was 5 (IQR 4\u20137). Undetectable MRD on PB at any timepoint was obtained in 34\/40 patients (85%): 82% in venetoclax monotherapy (Vmono) and 86.9% in VR group. Concordance of PB\/BM samples was 92% at 24\u00a0months. No significant difference in uMRD rates was detected based on del17p\/TP53mut and number of previous therapies. Three\u2010year progression\u2010free survival (PFS) for Vmono and VR was 53.5% and 55%. Median PFS in del17pl\/TP53mut was 29.8 and 34\u00a0months in Vmono and VR respectively. Landmark analysis based on 9\u2010month MRD showed a trend towards a better PFS in uMRD patients. Median PFS was 21.7 and 13.04\u00a0months in 24\u2010month uMRD and detectable MRD patients after VR, respectively (log rank\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0309). In conclusion, in these high\u2010risk relapsed\/refractory CLL patients who were MRD\u2010monitored in the context of a real\u2010life study the results were similar compared to published data in more selected patients.\n                  <\/jats:p>","DOI":"10.1002\/hon.70176","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:30:19Z","timestamp":1770712219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Monitoring of Measurable Residual Disease in Chronic Lymphocytic Leukemia Patients Treated With Venetoclax: Results of a Prospective Multicenter Real\u2010Life Study"],"prefix":"10.1002","volume":"44","author":[{"given":"Lucia","family":"Farina","sequence":"first","affiliation":[{"name":"Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Noto","sequence":"additional","affiliation":[{"name":"Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Aiello","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Innovation Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Motta","sequence":"additional","affiliation":[{"name":"S.C. Ematologia ASST Spedali Civili  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferrario","sequence":"additional","affiliation":[{"name":"Hematology ASST dei Sette Laghi\u2010Ospedale di Circolo  Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7393-1138","authenticated-orcid":false,"given":"Riccardo","family":"Moia","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Translational Medicine Universit\u00e0 del Piemonte Orientale and AOU Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Scarf\u00f2","sequence":"additional","affiliation":[{"name":"School of Medicine Universit\u00e0 Vita\u2010Salute San Raffaele  Milano Italy"},{"name":"Strategic Research Program on CLL IRCCS Ospedale San Raffaele  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-6107","authenticated-orcid":false,"given":"Marina","family":"Deodato","sequence":"additional","affiliation":[{"name":"Hematology Niguarda Cancer Center Niguarda Hospital  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Merli","sequence":"additional","affiliation":[{"name":"Hematology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Ljevar","sequence":"additional","affiliation":[{"name":"Biostatistics for Clinical Research Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Pruneri","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Innovation Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-1757","authenticated-orcid":false,"given":"Cristiana","family":"Carniti","sequence":"additional","affiliation":[{"name":"Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Corradini","sequence":"additional","affiliation":[{"name":"Hematology Fondazione IRCCS Istituto Nazionale dei Tumori  Milano Italy"},{"name":"Universit\u00e0 degli Studi di Milano  Milano 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