{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:05:55Z","timestamp":1783929955755,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ruxolitinib (RUX), a JAK1\/2 inhibitor, demonstrated treatment benefits for myelofibrosis (MF) in intermediate\u20101 (Int\u20101)\u2013risk patients with a significant disease burden; however, the evidence is scarce. This interim analysis investigated the efficacy and safety of ruxolitinib in patients with Int\u20101\u2010risk MF. ROMEI, a multicenter, observational, prospective study, enrolled 508 adult patients with MF receiving ruxolitinib according to approved indications. The present interim analysis was focused on 107 eligible patients in the Int\u20101\u2010risk group. Primary endpoints included changes in symptoms response and health\u2010related quality of life scores. Secondary endpoints included spleen response evaluation, overall survival, and safety including dosing pattern and dose interruptions. Among the 107 Int\u20101\u2010risk patients with a median age of 63\u00a0years, 65.5% were highly symptomatic (total symptoms score: \u2265 20), while the spleen was palpable at \u2265 5\u00a0cm and \u2265 10\u00a0cm in 74% and 27% of patients, respectively, with baseline EuroQol visual analogue scale (EQ\u2010VAS) score of 65.1\u00a0\u00b1\u00a019.4. After RUX treatment, 42.1% and 43.9% of patients demonstrated a symptom response at 24 and 48\u00a0weeks, while 38.9% and 46.8% showed a spleen response at 24 and 48\u00a0weeks, respectively. EQ\u2010VAS increased to 71.8\u00a0\u00b1\u00a016.3 at 24\u00a0weeks and 69.3\u00a0\u00b1\u00a019.2 at 48\u00a0weeks. Furthermore, 11.2% and 25.2% of patients reported temporary and permanent discontinuation, respectively with no new adverse events reported. The interim analysis showed that ruxolitinib provided clinical benefits, a manageable safety profile, and improved quality of life for Int\u20101\u2010risk subgroup patients with frequent and sustained responses with acceptable toxicity.<\/jats:p>","DOI":"10.1002\/hon.70178","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:32:57Z","timestamp":1774423977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Ruxolitinib Treatment in Patients With IPSS Intermediate\u20101\u2010Risk Myelofibrosis: Interim Analysis From an Italian, Prospective Study (ROMEI)"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-284X","authenticated-orcid":false,"given":"Paola","family":"Guglielmelli","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine CRIMM Center for Research and Innovation of Myeloproliferative Neoplasms AOU Careggi University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-6162","authenticated-orcid":false,"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Hematology Department of Translational and Precision Medicine Azienda Policlinico Umberto I Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mendicino","sequence":"additional","affiliation":[{"name":"A. 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