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Chimeric antigen receptor (CAR) T\u2010cell therapy is an innovative immunotherapy that has demonstrated remarkable efficacy in patients with relapsed\/refractory (R\/R) MM. To date, four B\u2010cell maturation antigen (BCMA)\u2010targeting CAR T\u2010cell therapies have been approved in the United States and China for the treatment of R\/R MM: idecabtagene vicleucel, ciltacabtagene autoleucel, equecabtagene autoleucel, and zevorcabtagene autoleucel. Although these four CAR T\u2010cell therapies have achieved encouraging response rates in R\/R MM, a comprehensive comparative analysis of their efficacy and toxicity profiles is still lacking. In this review, we compare the efficacy and safety of these four approved BCMA\u2010directed CAR T\u2010cell therapies. We also discuss potential factors underlying the observed differences and highlight strategies that may further improve the clinical outcomes of this revolutionary therapy.<\/jats:p>","DOI":"10.1002\/hon.70179","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:10:57Z","timestamp":1771679457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety Comparisons of Four Approved Chimeric Antigen Receptor T\u2010Cell Therapies in Multiple Myeloma"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9728-2173","authenticated-orcid":false,"given":"Zhiqiang","family":"Song","sequence":"first","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7564-6403","authenticated-orcid":false,"given":"Qingcheng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-4007","authenticated-orcid":false,"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology Myeloma &amp; Lymphoma Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"},{"name":"Department of Hematology Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201010\u2010078022"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010021\u201008280\u2010y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201009\u2010568915"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26590"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148882"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010017\u20100841\u2010y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010019\u20100435\u20107"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010023\u201000754\u20101"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002842"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.11.1693"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460\u20102075"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160213497"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031330"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201001\u2010691162"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201012\u20102422"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291\u2010024\u201000723\u2010z"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2024850"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102020\u2010134322"},{"key":"e_1_2_12_20_1","article-title":"Idecabtagene Vicleucel (Ide\u2010Cel) in Patients (Pts) With Triple\u2010Class\u2013Exposed (TCE) Relapsed and Refractory Multiple Myeloma (RRMM): The 5\u2010Year Follow\u2010Up Analysis From Karmma","author":"Larry A. 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