{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:11:15Z","timestamp":1775646675241,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bridging therapy (BT) is frequently used in patients with relapsed\/refractory (R\/R) large B\u2010cell lymphoma (LBCL) undergoing chimeric antigen receptor T cell (CAR T) therapy, but the optimal BT approach remains uncertain. We evaluated BT strategies and their associations with response and survival outcomes. Accordingly, we included patients with R\/R LBCL evaluated for third\u2010line or later CD19\u2010directed CAR T at Princess Margaret Cancer Center from 2017 to 2024 (follow\u2010up to 01\/2025). BT modalities included chemotherapy, polatuzumab\u2010based chemotherapy, radiotherapy, corticosteroids, and none. We assessed the associations of BT modality with overall response rate (ORR), progression\u2010free survival (PFS), and overall survival (OS) using logistic regression and Cox models. Among 219 patients, 188 underwent apheresis and 157 (84%) received CAR T. Of those apheresed, 79% received BT (radiotherapy 41%, polatuzumab\u2010based 26%, third\u2010line chemotherapy 16%, corticosteroids 17%, while 21% received no BT). ORR was highest with polatuzumab (50%) and radiotherapy (40%) versus chemotherapy (16%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.009). Median \u0394SUVmax in 84 patients was higher in polatuzumab and radiotherapy treated patients, compared to chemotherapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Radiotherapy encompassing all active disease had higher ORR (51%) versus non\u2010comprehensive (12%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.04). Two\u2010year PFS was highest with radiotherapy (47%) and polatuzumab (37%) BT versus chemotherapy (21%). Adjusted analyses showed improved PFS with radiotherapy (adjusted hazard ratio [aHR] 0.29) and polatuzumab (aHR 0.41). OS was also improved with radiotherapy (HR 0.40). Chemotherapy BT was associated with the highest 2\u2010year lymphoma\u2010related mortality (74%). In conclusion, polatuzumab\u2010based and radiotherapy BT as well as no BT were associated with improved responses and outcomes compared to chemotherapy. Although these results may have been influenced by patient selection, prospective studies integrating these approaches are needed to define optimal, individualized BT strategies.\n                  <\/jats:p>","DOI":"10.1002\/hon.70183","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:17:18Z","timestamp":1772993838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Bridging Therapy in Patients With Relapsed\/Refractory Large B Cell Lymphoma Receiving Third\u2010Line CAR T"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-2945","authenticated-orcid":false,"given":"Inna Y.","family":"Gong","sequence":"first","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Jeeva","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Radiation Medicine Program  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Hueniken","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Biostatistics  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Aminilari","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Radiation Medicine Program  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Marinoni","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Prica","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Rodin","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Radiation Medicine Program  Toronto Ontario Canada"},{"name":"Department of Radiation Oncology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sita","family":"Bhella","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-8361","authenticated-orcid":false,"given":"Tomohiro","family":"Aoki","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Azab","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-3669","authenticated-orcid":false,"given":"Christine","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-7124","authenticated-orcid":false,"given":"Robert","family":"Kridel","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Kukreti","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-1501","authenticated-orcid":false,"given":"Abi","family":"Vijenthira","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nauman","family":"Malik","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Radiation Medicine Program  Toronto Ontario Canada"},{"name":"Department of Radiation Oncology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woodrow","family":"Wells","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre Radiation Medicine Program  Toronto Ontario Canada"},{"name":"Faculty of 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