{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:07:54Z","timestamp":1791313674376,"version":"4.3.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>T\u2010cell lymphomas (TCLs) account for a relatively small fraction of lymphoid malignancies and are characterized by highly aggressive course often refractory to current available therapies. We previously reported potent in vitro and in vivo antitumor activity of a Bispecific T\u2010Cell Engager (UMG1\/CD3\u03b5\u2010BTCE) directed against UMG1, a unique CD43 epitope that is abundantly expressed on T\u2010cell acute lymphoblastic leukemia (T\u2010ALL) and diffuse large B\u2010cell lymphoma (DLBCL) cells, while absent in most normal tissues, except thymocytes and a small fraction of peripheral blood T lymphocytes (&lt;\u00a05%). Here, we investigated the in vitro efficacy of UMG1\/CD3\u03b5\u2010BTCE against TCLs. IHC analysis of Tissue Micro Arrays (TMAs) revealed high UMG1 expression in 62.3% of TCL samples, including peripheral T\u2010cell lymphoma\u2010not otherwise specified (PTCL\u2010NOS) and ALK\u2010negative anaplastic large cell lymphoma (ALCL). Notably, all T\u2010PLL primary specimens (27\/27) were positive, and 3 of 4 TCL cell lines also expressed UMG1 by flow cytometry. The asymmetric UMG1\/CD3\u03b5\u2010BTCE induced robust redirected cytotoxicity against UMG1\u2010expressing TCL cells. Moreover, this activity was strengthened by cell exposure to the HDAC inhibitor SAHA. We observed a dose\u2010dependent engaged T\u2010cell\u2010mediated cytotoxicity and inflammatory cytokine release, resulting in lysis of UMG1\u2010expressing cells, with no significant effect on UMG1\u2010not expressing cells. Our findings suggest that the UMG1\/CD3\u03b5\u2010BTCE selectively exerts potent anti\u2010tumor activity against a relevant subset of TCLs. These findings support the development of a precision immunotherapy approach for patients with UMG1\u2010expressing aggressive hematologic malignancies.<\/jats:p>","DOI":"10.1002\/hon.70187","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:23:41Z","timestamp":1773642221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["UMG1 Defines a Targetable Subset of T\u2010Cell Lymphomas and Enables Precision Immunotherapy With a First\u2010in\u2010Class CD3\u03b5 Bispecific Engager"],"prefix":"10.1002","volume":"44","author":[{"given":"Daniele","family":"Caracciolo","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Squillacioti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Signorelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Riillo","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinuccia","family":"Faviana","sequence":"additional","affiliation":[{"name":"Department of Surgical Medical Molecular Pathology and Critical Area University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Conforti","sequence":"additional","affiliation":[{"name":"Pathology Unit Annunziata Hospital  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"De Ieso","sequence":"additional","affiliation":[{"name":"Department of Surgical Medical Molecular Pathology and Critical Area University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Procopio","sequence":"additional","affiliation":[{"name":"Pathology Unit A.O.U Dulbecco  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Altomare","sequence":"additional","affiliation":[{"name":"IRIB\u2010CNR  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Poler\u00e0","sequence":"additional","affiliation":[{"name":"IRIB\u2010CNR  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gaetano","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Balducci","sequence":"additional","affiliation":[{"name":"Laboratory of Onco\u2010Hematology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Necker Enfants\u2010Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Beganovic","sequence":"additional","affiliation":[{"name":"Laboratory of Onco\u2010Hematology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Necker Enfants\u2010Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca Maria","family":"Tuccillo","sequence":"additional","affiliation":[{"name":"Molecular Biology and Viral Oncology Unit 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierosandro","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Tassone","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine (DMSC) Magna Graecia University  Catanzaro 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