{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:52:43Z","timestamp":1780987963356,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502600"],"award-info":[{"award-number":["2022YFC2502600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82530008, 82130004, 81900193, 82400230, and 82400224"],"award-info":[{"award-number":["82530008, 82130004, 81900193, 82400230, and 82400224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772231"],"award-info":[{"award-number":["2025M772231"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Concurrent follicular and diffuse large B\u2010cell lymphoma (FL\/DLBCL) and transformed follicular lymphoma (tFL) are distinct B\u2010cell lymphoma entities, posing challenges for understanding pathogenesis and clinical management. The clinical characteristics of 98 FL\/DLBCL, 31 tFL, 403 FL1\u20102\/3A, and 608 DLBCL patients were analyzed. DNA sequencing was performed in these cohorts, and RNA sequencing was performed on 60 FL\/DLBCL, 8 tFL, 175 FL1\u20102\/3A, and 329 DLBCL patients. FL\/DLBCL was characterized by localized disease, whereas tFL was associated with elevated LDH levels. Genomic analyses revealed that FL\/DLBCL harbored frequent mutations in the Wnt signaling pathway but lacked the epigenetic alterations observed in FL, while tFL retained FL\u2010associated epigenetic mutations and acquired additional alterations in cell cycle\/p53 and JAK\u2010STAT pathways. Both FL\/DLBCL and tFL exhibited increased gene mutations related to the tumor microenvironment and B\u2010cell differentiation, most notably CD70 and CD79B. Transcriptomic profiling further demonstrated enrichment of tumor microenvironment and B\u2010cell differentiation\u2010related pathways, consistent with the mutational landscape. Functionally, co\u2010culture assays showed that knockdown of CD70 in B\u2010lymphoma cells reduced naive CD4+ and CD8+ T\u2010cell subsets, whereas CD79B\n                    <jats:sup>Y197H<\/jats:sup>\n                    transfected B\u2010lymphoma cells enhanced tumor cell viability. Our findings comprehensively characterize FL\/DLBCL and tFL molecularly, elucidating their distinct pathogenesis and rationalize CD70 and CD79B targeted immunotherapies.\n                  <\/jats:p>","DOI":"10.1002\/hon.70188","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:43:13Z","timestamp":1773906193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic and Transcriptomic Profiles Identify Potential Therapeutic Targets of Concurrent Follicular and Diffuse Large B\u2010Cell Lymphoma and Transformed Follicular Lymphoma"],"prefix":"10.1002","volume":"44","author":[{"given":"Rui","family":"Sun","sequence":"first","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 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Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Tian","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 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Sciences and Biotechnology Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key 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