{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:10:10Z","timestamp":1780308610517,"version":"3.54.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>BTK inhibitors (BTKi) have reshaped the therapeutic algorithm of lymphoproliferative diseases, but class\u2010specific adverse events (AEs) have emerged. Dose adjustment (DA) is often attempted to mitigate AEs, particularly with ibrutinib, the first BTKi approved for relapsed\/refractory (R\/R) mantle cell lymphoma (MCL) patients. We described ibrutinib DA in 226 consecutive R\/R MCL who started ibrutinib between 2016 and 2023. We assessed DA rate and calculated single patient's relative ibrutinib dose as a percentage of the expected full dose during the entire treatment period, grouping patients into 4 dose levels (DL1a 95%\u2013100%, DL1b 75%\u201394%, DL2a 50%\u201374%, DL2b &lt; 50%). We evaluated changes in response, progression free survival (PFS), overall survival (OS) and time to next treatment (TTNT) between groups. Thirty\u2010four percent of patients started ibrutinib at reduced dose, mainly due to age\/comorbidities. Overall, 44% of patients reduced ibrutinib dose, mostly due to AEs. Thirty\u2010five percent of patients interrupted treatment, predominantly for AEs, and 65% of patients discontinued ibrutinib, most often due to progressive disease (70%). No statistically significant differences in response rates\/PFS\/OS were observed across DLs. Interestingly, patients on the lowest dose tended to remain on treatment longer. This is the first real\u2010life report evaluating ibrutinib DA in MCL. We showed that DA is common, particularly in older comorbid patients, and doesn't compromise efficacy, making it a feasible strategy for managing ibrutinib\u2010related toxicities.<\/jats:p>","DOI":"10.1002\/hon.70190","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:19:18Z","timestamp":1775146758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ibrutinib Dose Adjustment Does Not Impair Treatment Outcome in Mantle Cell Lymphoma: An Italian Real\u2010Life Multicenter Experience. Results From the REDOT_MCL Study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-3775","authenticated-orcid":false,"given":"Francesca Maria","family":"Quaglia","sequence":"first","affiliation":[{"name":"UOC di Ematologia, DAI Medico Generale, AOUI Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Mannelli","sequence":"additional","affiliation":[{"name":"Unit of Oncohematology Department of Oncology Azienda USL Toscana Centro  Prato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Universit\u00e0 Degli Studi di Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Scapinello","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Universitario di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Schiattone","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Ematologia Ospedale Civile S. Spirito  Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Farina","sequence":"additional","affiliation":[{"name":"Unit of Blood Diseases and Bone Marrow Transplantation Cell Therapies and Hematology Research Program University of Brescia ASST Spedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Novo","sequence":"additional","affiliation":[{"name":"Hematology Division A.O.U. Citt\u00e0 Della Salute e Della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Angelillo","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Scientific Institute  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCSS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Maiolo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio Ed Ematologiche Fondazione Policlinico Universitario a. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Lucchini","sequence":"additional","affiliation":[{"name":"UCO Ematologia Azienda Sanitaria Universitaria Giuliano Isontina  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Tomarchio","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Hematology Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ghiggi","sequence":"additional","affiliation":[{"name":"U.O. Ematologia e Terapie Cellulari IRCCS Ospedale Policlinico San Martino  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Pelliccia","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Ematologia Dipartimento di Medicina Clinica e Molecolare Azienda Ospedaliera Universitaria Sant'Andrea Universit\u00e0 Sapienza  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Marangon","sequence":"additional","affiliation":[{"name":"Oncoematologia Trapianti Emopoietici e Terapie Cellulari \u2010 IRCCS Centro di Riferimento Oncologico \u2010 Aviano (PN)  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Fondazione Italiana Linfomi  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-8817","authenticated-orcid":false,"given":"Francesco","family":"Zaja","sequence":"additional","affiliation":[{"name":"UCO Ematologia Azienda Sanitaria Universitaria Giuliano Isontina  Trieste Italy"},{"name":"DSM Universit\u00e0 Degli Studi di Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509388"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201003\u2010635326"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501548"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006844"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.00555"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003121"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020507"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.182907"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000118"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18643"},{"key":"e_1_2_13_12_1","unstructured":"S.Sarosiek S. 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