{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:10:05Z","timestamp":1780308605714,"version":"3.54.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oligo\u2010secretory and non\u2010secretory MM present a clinical challenge due to the difficulties in initial diagnosis, response to treatment assessment, and relapse detection. They are excluded from most clinical trials, which typically require measurable disease. We describe the characteristics and outcomes of 86 patients with secretory myeloma at diagnosis who developed an OSR, matched 1:1 to a cohort with secretory relapse (SR). With a median follow\u2010up of 9.3\u00a0years, 16.6% (48\/289) of evaluable patients developed an OSR. Lower levels of light chains at presentation, and younger age are predictive of an OSR. The median OS since relapse of the OSR group was 4.01 (95% CI 1.625\u20136.395) versus 3.25 (95% CI 2.255\u20134.245) years in the SR control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.4). A third of our OSR cohort had a subsequent SR. We did not find any predictive factor for SR after OSR. The median OS of the subgroup of patients who developed a SR after OSR was 3.35\u00a0years (95% CI 1.541\u20135.159), versus 5.8\u00a0years (95% CI 2.072\u20139.528) in the group that remained oligo\u2010secretory (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.336). The median TTNT of the SR after OSR group was 1.68\u00a0years (95% CI 0.341\u20130.919) versus 4.58 (95% CI not reached\u2010not reached) in the group that remained oligo\u2010secretory (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001).\n                  <\/jats:p>","DOI":"10.1002\/hon.70192","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:15:38Z","timestamp":1775553338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Clinical Characteristics and Outcomes of Multiple Myeloma Patients With Oligo or Non\u2013Secretory Relapse\u2014A Retrospective Cohort Study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-064X","authenticated-orcid":false,"given":"Iuliana","family":"Vaxman","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"},{"name":"Institute of Hematology Davidoff Cancer Center Rabin Medical Center Petah Tikvah  Petah Tikvah Israel"},{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itai","family":"Zamir","sequence":"additional","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center Rabin Medical Center Petah Tikvah  Petah Tikvah Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbar","family":"Cohen","sequence":"additional","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center Rabin Medical Center Petah Tikvah  Petah Tikvah Israel"},{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Fridberg","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3741-689X","authenticated-orcid":false,"given":"Tamir","family":"Shragai","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Trestman","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer Ziv","family":"Baran","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences School of Public Health Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Luttwak","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Shmuel","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natan","family":"Melamed","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-9029","authenticated-orcid":false,"given":"Shai","family":"Levy","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Avivi","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Raanani","sequence":"additional","affiliation":[{"name":"Institute of Hematology Davidoff Cancer Center Rabin Medical Center Petah Tikvah  Petah Tikvah Israel"},{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3853-5196","authenticated-orcid":false,"given":"Morie A.","family":"Gertz","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael C.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27422"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)30206\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc1206740"},{"issue":"3","key":"e_1_2_10_6_1","first-page":"428","article-title":"Intracytoplasmic and Surface\u2010Bound Immunoglobulins in \u201cNonsecretory\u201d and Bence\u2010Jones Myeloma","volume":"25","author":"Preud'Homme J. L.","year":"1976","journal-title":"Clinical and Experimental Immunology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201002\u20100477"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102002\u201008\u20102436"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001180\u2010x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-207595"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010020\u201003984\u2010w"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.70192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:56:30Z","timestamp":1780307790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.70192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/hon.70192"],"URL":"https:\/\/doi.org\/10.1002\/hon.70192","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.70192\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.70192\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70192"}}