{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:10:05Z","timestamp":1780308605222,"version":"3.54.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hairy cell leukemia variant (HCL\u2010v) is a rare B\u2010cell malignancy with limited treatment options in relapsed or refractory settings. We describe the first reported case of chemo\u2010refractory HCL\u2010v successfully treated with zanubrutinib monotherapy. An 84\u2010year\u2010old man, previously refractory to rituximab and bendamustine, achieved early hematologic improvement and reduction in spleen size after starting zanubrutinib, with a sustained clinical and laboratory response at 17\u00a0months. A clinical study with ibrutinib has shown durable disease control in classic and variant HCL, supporting BTK inhibition as a therapeutic strategy. This case suggests zanubrutinib as a promising chemo\u2010free option for frail HCL\u2010v patients.<\/jats:p>","DOI":"10.1002\/hon.70194","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:56:05Z","timestamp":1777352165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zanubrutinib in Hairy Cell Leukemia Variant: Clinical Report and Overview of BTK Inhibition in Variant Disease"],"prefix":"10.1002","volume":"44","author":[{"given":"A.","family":"Bernardelli","sequence":"first","affiliation":[{"name":"UOC di Ematologia e CTMO DAI Medico Generale Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Carazzai","sequence":"additional","affiliation":[{"name":"Section of Biomedicine of Innovation Department of Engineering for Innovative Medicine (DIMI) Hematology and Bone Marrow Transplant Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mion","sequence":"additional","affiliation":[{"name":"Section of Biomedicine of Innovation Department of Engineering for Innovative Medicine (DIMI) Hematology and Bone Marrow Transplant Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Serafin","sequence":"additional","affiliation":[{"name":"Section of Biomedicine of Innovation Department of Engineering for Innovative Medicine (DIMI) Hematology and Bone Marrow Transplant Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ferrarini","sequence":"additional","affiliation":[{"name":"Section of Biomedicine of Innovation Department of Engineering for Innovative Medicine (DIMI) Hematology and Bone Marrow Transplant Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-2040","authenticated-orcid":false,"given":"M.","family":"Krampera","sequence":"additional","affiliation":[{"name":"UOC di Ematologia e CTMO DAI Medico Generale Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"},{"name":"Section of Biomedicine of Innovation Department of Engineering for Innovative Medicine (DIMI) Hematology and Bone Marrow Transplant Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Visco","sequence":"additional","affiliation":[{"name":"UOC di Ematologia e CTMO DAI Medico Generale Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"},{"name":"Section of Biomedicine of Innovation Department of Engineering for Innovative Medicine (DIMI) Hematology and Bone Marrow Transplant Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_3_2_1","first-page":"380","volume-title":"Haematolymphoid Tumours. 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