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Histone deacetylase inhibitor chidamide has demonstrated its anti\u2010tumor effects in real\u2010world studies in relapsed or refractory PTCL. To evaluate the efficacy of real\u2010world utilization of chidamide combined with chemotherapy for untreated PTCL and explore relative prognostic factors, a cohort of 151 PTCL patients treated with chidamide combined with chemotherapy as front\u2010line treatment in our center were enrolled. The overall response rate (ORR) and complete remission rate (CRR) at the end of treatment were 81.5% and 67.5%. The 7\u2010year overall survival (OS) rate and progression\u2010free survival (PFS) rate were 67.6% and 49.7%, with a median follow\u2010up period of 21\u00a0months, showing its satisfactory efficacy and survival advantage. Most of adverse events were transient and reversible. Furthermore, several baseline characteristics of patients were relevant to prognosis. The study identified gene mutations in\n                    <jats:italic>TET2<\/jats:italic>\n                    (30.9%),\n                    <jats:italic>STAT<\/jats:italic>\n                    (22.7%),\n                    <jats:italic>RHOA<\/jats:italic>\n                    (17.5%),\n                    <jats:italic>TP53<\/jats:italic>\n                    (14.4%),\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    (12.4%), with\n                    <jats:italic>TP53<\/jats:italic>\n                    and\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    mutations correlating with worse clinical outcomes. The identification of gene mutations contributed to personalizing treatment strategies and predicting patient outcomes. This study raised the preliminary hypothesis that chidamide\u2010containing front\u2010line therapy might be promising for PTCL patients, which warranted further investigation.\n                  <\/jats:p>","DOI":"10.1002\/hon.70195","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:59:21Z","timestamp":1777730361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Follow\u2010Up of Chidamide With Chemotherapy in Untreated Peripheral T\u2010Cell Lymphoma: One Single Center Real\u2010World Study in China"],"prefix":"10.1002","volume":"44","author":[{"given":"Jiajie","family":"He","sequence":"first","affiliation":[{"name":"Department of Hematology the First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology the First Affiliated Hospital of Soochow University  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