{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:40:32Z","timestamp":1780605632765,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG\u201025024"],"award-info":[{"award-number":["IG\u201025024"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hodgkin\u2010variant Richter's transformation (HvRT) is a rare evolution of chronic lymphocytic leukemia (CLL) into a lymphoma with histological characteristics akin to those of classical Hodgkin lymphoma (cHL), overall occurring in &lt;\u00a01% of CLL cases. Due to its rarity, treatment is not standardized and is commonly adapted from cHL regimens, although toxicity limits their use in older or heavily pretreated patients. We describe two cases of HvRT treated with a modified sequential brentuximab vedotin\u2010AVD\u2010brentuximab vedotin (BV\u2010AVD\u2010BV) regimen, previously explored in elderly patients with cHL. Sequential BV\u2010AVD\u2010BV was feasible and manageable in both cases, with acceptable hematologic toxicity. One patient achieved a durable complete metabolic remission, while the other required immune checkpoint inhibitor\u2010based salvage therapy followed by autologous stem cell transplantation, resulting in complete metabolic response. These cases suggest that sequential BV\u2010AVD\u2010BV may represent a tolerable and effective therapeutic option for selected patients with HvRT. Incorporation of modern Hodgkin\u2010directed strategies, including sequential regimens and immune checkpoint inhibitors, warrants further evaluation in this rare clinical setting.<\/jats:p>","DOI":"10.1002\/hon.70197","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:30:27Z","timestamp":1778671827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sequential BV\u2010AVD Therapy in Richter Transformation: Insights Into the Management of Elderly Patients"],"prefix":"10.1002","volume":"44","author":[{"given":"Arianna","family":"Bevilacqua","sequence":"first","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cellini","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Danesin","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Angotzi","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Serafin","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6109-2274","authenticated-orcid":false,"given":"Giovanni","family":"Leone","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"D'Antiga","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-623X","authenticated-orcid":false,"given":"Francesco","family":"Piazza","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pizzi","sequence":"additional","affiliation":[{"name":"Surgical Pathology and Cytopathology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Trentin","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Visentin","sequence":"additional","affiliation":[{"name":"Hematology Unit Department of Medicine University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u20100797\u2010x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.278304"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23939"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.256388"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/7612622"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.278438"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.79.0139"},{"issue":"2","key":"e_1_2_3_9_1","first-page":"785","article-title":"Hodgkin\u2019s Variant of Richter Transformation in Chronic Lymphocytic Leukemia; A Retrospective Study From the Israeli CLL Study Group","volume":"34","author":"Tadmor T.","year":"2014","journal-title":"Anticancer Research"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2011.08907.x"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201025\u201000204"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24714"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.70197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:56:23Z","timestamp":1780307783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.70197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/hon.70197"],"URL":"https:\/\/doi.org\/10.1002\/hon.70197","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70197"}}