{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:10:04Z","timestamp":1780308604112,"version":"3.54.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Angioimmunoblastic T\u2010cell lymphoma (AITL) is a rare, aggressive subtype of peripheral T\u2010cell lymphoma. Whole population studies of AITL are infrequent and often grouped along with other T\u2010cell lymphomas. We undertook a population\u2010based study using ICD\u2010O3\u2010coded cases of AITL diagnosed 2013\u20132019 in order to establish AITL epidemiology in England, along with survival outcomes and associated diagnoses. We identified 993 cases, with a median age of 71\u00a0years. Overall incidence was 2.57 cases\/million person\u2010years (95% CI 2.41\u20132.74). The incidence increased with age, ranging from 0.24 cases\/million person\u2010years at 0\u201349\u00a0years (CI 0.19\u20130.31) to 11.56 in \u2265\u00a070\u00a0years (CI 10.62\u201312.55), and was lower in females (incidence rate ratio [IRR] 0.74, CI 0.66\u20130.84). One and 3\u2010year overall survival (OS) were 58% and 37% respectively. 151 patients received auto\u2010SCT, with a 1\u2010year and 3\u2010year OS from transplant of 78.9% and 65.8%. In multivariable analysis, gender (hazard ratio [HR] in females\u00a0=\u00a00.77, 95% CI 0.66\u20130.90) and age (HR in \u2265\u00a080\u00a0years\u00a0=\u00a04.41, CI 2.86\u20136.79) impacted OS. 142 patients developed an associated B\u2010cell lymphoma or Hodgkin lymphoma (14.3%). A diagnosis of autoimmune hemolytic anemia (AIHA) was reported in 56 patients (5.6%), and immune thrombocytopenic purpura (ITP) in 14 (1.4%). Our study defines AITL incidence for the first time in England, confirms OS in an unselected population, and describes rates of autoimmune disease and B\u2010cell lymphomas. Gender and age are the primary characteristics that influence outcomes.<\/jats:p>","DOI":"10.1002\/hon.70199","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:41:54Z","timestamp":1779104514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Survival of Patients With Angioimmunoblastic T\u2010Cell Lymphoma: A Nationwide Population\u2010Based Study Using English Cancer Registration Data"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0326-5912","authenticated-orcid":false,"given":"Sarah J.","family":"Halligan","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Grainge","sequence":"additional","affiliation":[{"name":"Lifespan and Population Health School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-1036","authenticated-orcid":false,"given":"Mark J.","family":"Bishton","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001620\u20102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201009\u2010692541"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.3647"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.126300"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2021.100126"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.63.5540"},{"key":"e_1_2_11_9_1","unstructured":"\u201cHMRN Incidence: Haematological Malignancy Research Network (HMRN)\u2014Incidence Statistics.\u201d [Internet]. 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[cited 2025 Jun 6] https:\/\/www.gov.uk\/government\/statistics\/english\u2010indices\u2010of\u2010deprivation\u20102019."},{"key":"e_1_2_11_26_1","unstructured":"\u201cEstimates of the Population for England and Wales\u2014Office for National Statistics.\u201d [Internet]. 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