{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:19:13Z","timestamp":1788279553201,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Older patients with classical Hodgkin lymphoma (cHL) have poorer outcomes than younger patients, largely due to comorbidities, reduced chemotherapy tolerance, and limited representation in clinical trials. Brentuximab Vedotin (BV) and PD\u20101 inhibitors have entered frontline use in this population, but the optimal approach remains uncertain. We performed a systematic review and pooled analysis to evaluate the efficacy and safety of frontline regimens in patients aged \u2265 60\u00a0years with cHL. Studies reporting complete response (CR), overall response rate (ORR), progression\u2010free survival (PFS), and toxicity were included. Outcomes were pooled using random\u2010effects models. A total of 11 studies including 568 patients were analyzed. The pooled CR rate was 71% (95% CI: 57\u201381) and pooled 2\u2010year PFS was 66% (95% CI: 45\u201383), with significant heterogeneity. Nivolumab\u2010based regimens appeared, in indirect subgroup comparisons with marked heterogeneity, to have a higher pooled response rates and PFS than BV\u2010based regimens, and were associated with lower rates of treatment discontinuation, Grade \u2265 3 infections, and neuropathy. Novel agent\u2010based regimens produced better efficacy and lower toxicity than traditional chemotherapy in newly diagnosed older adults with cHL. Among novel agents, nivolumab\u2010based regimens had more favorable efficacy and tolerability than BV\u2010based regimens, though these comparisons are indirect and may reflect differences in study design and patient selection.<\/jats:p>","DOI":"10.1002\/hon.70215","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:47:01Z","timestamp":1782150421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Novel\u2010Agent\u2013Based Front\u2010Line Therapy in Older Adults Aged \u2265 60\u00a0Years With Classic Hodgkin Lymphoma: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7703-4696","authenticated-orcid":false,"given":"Rudra Narayan","family":"Swain","sequence":"first","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology Postgraduate Institute of Medical 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