{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:19:13Z","timestamp":1788279553164,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7262050"],"award-info":[{"award-number":["7262050"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX202137"],"award-info":[{"award-number":["ZYLX202137"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aberrant protein glycosylation is pivotal in cancer progression. However, the IgA glycosylation landscape in multiple myeloma (MM) and its regulatory mechanisms remain uncharacterized. We conducted a comprehensive glycoproteomic analysis of site\u2010specific N\u2010glycosylation at IgA1\u2010Asn144 across a large cohort, including newly diagnosed MM patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a050), healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a038), and longitudinal samples from various remission stages. Analysis was performed using Zeno trap\u2010equipped time\u2010of\u2010flight mass spectrometry. We identified a significant upregulation of fucosylated N\u2010glycopeptides in MM. A diagnostic model based on two fucosylated glycopeptides showed potential diagnostic utility (AUC\u00a0=\u00a00.808). Attaining deep therapeutic remission was associated with a marked loss of fucosylation and downregulation of hypersialylated glycans. Bioinformatics analysis pinpointed the fucosyltransferase FUT8 as a key differentially expressed regulator, which was subsequently validated to be elevated in MM at both RNA and protein levels. FUT8 promotes tumor progression by activating Wnt\/\u03b2\u2010catenin signaling and EMT\u2010associated pathways, thereby enhancing MM\u00a0cell proliferation, migration, and invasiveness. These findings identify FUT8 as a potential prognostic biomarker and a therapeutic target in MM.\n                  <\/jats:p>","DOI":"10.1002\/hon.70216","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T17:01:37Z","timestamp":1782579697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Glycoproteomics Identifies Dynamic IgA1 N\u2010Glycosylation and FUT8 as a Functional Mediator in Multiple Myeloma"],"prefix":"10.1002","volume":"44","author":[{"given":"Xu","family":"Si","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Beijing Chao\u2010yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-7320","authenticated-orcid":false,"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Civil Aviation General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Chao\u2010yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Chao\u2010yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Chao\u2010yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Chao\u2010yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7258-8745","authenticated-orcid":false,"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Beijing Chao\u2010yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178224219868235"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14213"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.08.019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cww086"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.1.21"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010024\u201000529\u20107"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141702"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00654"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b01071"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.146089"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201200131"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719\u2010011\u20109364\u2010z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010025\u201002088\u20100"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27955"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac500335t"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010022\u201000128\u20104"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5cs00600g"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103541"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae973"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.7554\/elife.83947"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2023.100562"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c03069"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5c00253"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr200102h"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.146774"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-25-0483"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217995"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201003\u2010560862"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2025.167900"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u201011\u201031"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112569"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205455"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010455"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021068"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/abt\/tbad004"}],"container-title":["Hematological 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