{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:46:29Z","timestamp":1792406789536,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The prognosis of Richter Transformation (RT) with standard chemo\u2010immunotherapy (CIT) remains poor. Several previous experiences with Venetoclax (V) in combination with CIT demonstrated the feasibility and safety of V\u2010CIT based regimens in RT. This is a retrospective, observational multicenter study aimed to assess the efficacy and safety of the\n                    <jats:italic>real\u2010life<\/jats:italic>\n                    use of V\u2010CIT in the treatment of RT. Response assessments were evaluated according to the Lugano 2014 criteria. 20 consecutive patients treated with V\u2010CIT based regimens from October 2018 to July 2024, were included. Median age was 63.5\u00a0years (33\u201373), with 75% of males. 11\/17 were IGHV unmutated and 8\/18 carried a mutation for Tp53 and\/or a del17p. The median time from CLL diagnosis to RT was 6.5\u00a0years (0\u201317). A clonal relationship was demonstrated in 16\/16 evaluable patients. The median number of prior treatments for CLL was 2 (0\u20134): CIT in 10, BTKi in 10, V based treatment in 4, no previous therapy in 5. V was associated with R\u2010DA\u2010EPOCH, R\u2010CHOP, and BFM in 10, 9 and 1 patients for a median number of 4 cycles (1\u20136). ORR was 55% with 10 CR (50%) and 1 PR (5%). 3 patients had progressive disease (PD) and 1 died for multiorgan failure. 7 patients received allogeneic\u2010HSCT consolidation. At a median follow up of 11.5\u00a0months (1\u201378), 10 patients, including 5 who received HSCT, are alive in CR; median PFS and OS were not reached. All patients experienced grade 3\u20104 hematological toxicities: neutropenia (100%), anemia (50%) and thrombocytopenia (25%). Non\u2010hematological toxicities included: febrile neutropenia (15%), covid19 (25%), other infections (30%), nausea (10%), thrombotic\/hemorrhagic events (10%). Data from this\n                    <jats:italic>real\u2010life<\/jats:italic>\n                    experience confirm the feasibility and the activity of V\u2010CIT based combination in younger fit RT patients, where the high rate of initial response may allow a significant proportion to receive allogeneic\u2010HSCT consolidation. New studies with V combinations are ongoing and the comparison with this\n                    <jats:italic>real\u2010life<\/jats:italic>\n                    data may be worthwhile to better understand their therapeutic impact.\n                  <\/jats:p>","DOI":"10.1002\/hon.70223","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:25:08Z","timestamp":1786987508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Venetoclax in Combination With Chemo\u2010Immunotherapy in Richter Transformation:\n                    <i>A Real\u2010Life<\/i>\n                    Experience"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-2074","authenticated-orcid":false,"given":"L.","family":"Ballotta","sequence":"first","affiliation":[{"name":"UCO Ematologia ASUGI Azienda Sanitaria Universitaria Giuliano Isontina Ospedale Maggiore Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Clinica di Ematologia Centro Trapianti e Terapie Cellulari Carlo Melzi ASUFC\u2014Azienda Sanitaria Universitaria Friuli Centrale\u2014Ospedale Civile \u201cSanta Maria della Misericordia\u201d Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Facchinelli","sequence":"additional","affiliation":[{"name":"UOC Ematologia ULSS8 Ospedale San Bortolo di Vicenza  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ferrarini","sequence":"additional","affiliation":[{"name":"Hematology Unit Section of Biomedicine of Innovation Department of Engineering for Innovation Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Visentin","sequence":"additional","affiliation":[{"name":"U.O. di Ematologia Dipartimento di Medicina Universit\u00e0 di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7393-1138","authenticated-orcid":false,"given":"R.","family":"Moia","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia Dipartimento di Medicina Traslazionale Universit\u00e0 del Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cavallari","sequence":"additional","affiliation":[{"name":"U.O. Ematologia ULSS3 Serenissima Ospedale dell'Angelo  Venezia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Innao","sequence":"additional","affiliation":[{"name":"U.O.C Ematologia A.R.N.A.S. Garibaldi  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-8140","authenticated-orcid":false,"given":"E.","family":"Derenzini","sequence":"additional","affiliation":[{"name":"Divisione di Oncoematologia Istituto Europeo Oncologico (IEO)  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Nierychlewska","sequence":"additional","affiliation":[{"name":"Divisione di Oncoematologia Istituto Europeo Oncologico (IEO)  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cuda","sequence":"additional","affiliation":[{"name":"SC Direzione Medica Cattinara e Maggiore ASUGI Azienda Sanitaria Universitaria Giuliano Isontina  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gattei","sequence":"additional","affiliation":[{"name":"Centro di Riferimento Oncologico (CRO) IRCCS SOC Onco\u2010Ematologia Clinico Sperimentale  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ballerini","sequence":"additional","affiliation":[{"name":"UCO Ematologia ASUGI Azienda Sanitaria Universitaria Giuliano Isontina Ospedale Maggiore Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-8325","authenticated-orcid":false,"given":"E.","family":"Lucchini","sequence":"additional","affiliation":[{"name":"UCO Ematologia ASUGI Azienda Sanitaria Universitaria Giuliano Isontina Ospedale Maggiore Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Turoldo","sequence":"additional","affiliation":[{"name":"UCO Ematologia ASUGI Azienda Sanitaria Universitaria Giuliano Isontina Ospedale Maggiore Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Clinical Research Coordinator UCO Ematologia ASUGI Azienda Sanitaria Universitaria Giuliano Isontina Ospedale Maggiore Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gaudio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery LUM University \u201cGiuseppe Degennaro\u201d  Casamassima Italy"},{"name":"Hematology Unit \u2010 Ecclesiastical Entity Regional General Hospital \u201cF. Miulli\u201d  Acquaviva delle Fonti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-8817","authenticated-orcid":false,"given":"F.","family":"Zaja","sequence":"additional","affiliation":[{"name":"UCO Ematologia ASUGI Azienda Sanitaria Universitaria Giuliano Isontina Ospedale Maggiore Trieste  Trieste Italy"},{"name":"Dipartimento Universitario Clinico di Scienze Mediche Chirurgiche e della Salute Universit\u00e0 di Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201001\u2010293050"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.03.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23841"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14177"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2020.05.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.06.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201012\u2010610782"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15440"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201012\u2010617522"},{"key":"e_1_2_8_12_1","first-page":"471","volume-title":"ASH Annual Meeting and Exposition","author":"Hillmen P.","year":"2016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15508"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201002\u2010765685"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16762"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.70.4320"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011386"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012080"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109064589"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.05.0187"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.37.4108"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3164_343"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010154279"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(24)00396\u20106"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.70223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:14:10Z","timestamp":1792404850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.70223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/hon.70223"],"URL":"https:\/\/doi.org\/10.1002\/hon.70223","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70223"}}