{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:19:11Z","timestamp":1788279551355,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502700"],"award-info":[{"award-number":["2022YFC2502700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970138"],"award-info":[{"award-number":["81970138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270165"],"award-info":[{"award-number":["82270165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470174"],"award-info":[{"award-number":["82470174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Post\u2010transplant relapse remains a major challenge in T\u2010ALL, with limited effective salvage options. We report on eight T\u2010ALL patients who received low\u2010dose chidamide (5\u00a0mg once weekly) as maintenance therapy after allogeneic HSCT. With a median follow\u2010up of 22.7\u00a0months, the estimated 2\u2010year OS and EFS are both 87.5%. Seven patients (87.5%) remain in continuous complete remission with sustained MRD negativity. Grade 3\u20134 neutropenia occurred in 57.1% of evaluable patients but was clinically manageable. This case series demonstrates that a low\u2010dose chidamide maintenance regimen is feasible, well tolerated, and promising in this setting.<\/jats:p>","DOI":"10.1002\/hon.70225","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:04:53Z","timestamp":1784030693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Dose Chidamide Maintenance Therapy After Hematopoietic Stem Cell Transplantation for T\u2010Cell Acute Lymphoblastic Leukemia: A Case Series"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0665-460X","authenticated-orcid":false,"given":"Shen\u2010Hao","family":"Liu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010Ni","family":"Deng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ying","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Fan","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Man","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-6935","authenticated-orcid":false,"given":"Han\u2010Yu","family":"Cao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"},{"name":"Medical Faculty Heidelberg and Department of Internal Medicine V, Hematology, Oncology and Rheumatology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Ling","family":"Wan","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Ping","family":"Dai","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-616X","authenticated-orcid":false,"given":"Sheng\u2010Li","family":"Xue","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation Collaborative Innovation Center of Hematology Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)00864\u20105"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684\u2010021\u20100877\u2010y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003214"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010023\u201002045\u2010w"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1096529"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022920"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.351"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010011\u20101766\u2010x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364\u2010025\u201000810\u20101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2023.8791"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102025\u2010169"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2024.2356300"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2024.102119"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.70225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.70225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:36:30Z","timestamp":1788276990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.70225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/hon.70225"],"URL":"https:\/\/doi.org\/10.1002\/hon.70225","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70225"}}