{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:59:45Z","timestamp":1790621985841,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K16142"],"award-info":[{"award-number":["21K16142"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010446","name":"Institute for Basic Science","doi-asserted-by":"publisher","award":["(IBS\u2010R022\u2010D1)"],"award-info":[{"award-number":["(IBS\u2010R022\u2010D1)"]}],"id":[{"id":"10.13039\/501100010446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005456","name":"Association of Zoos and Aquariums","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    BCL6 is a master transcriptional regulator of germinal center (GC) B cells.\n                    <jats:italic>BCL6<\/jats:italic>\n                    is frequently translocated at the major translocation cluster (MTC) within intron 1 of the\n                    <jats:italic>BCL6<\/jats:italic>\n                    locus, a hotspot commonly rearranged in diffuse large B cell lymphomas (DLBCLs).\n                    <jats:italic>BCL6<\/jats:italic>\n                    amplifications are associated with therapeutic resistance and poor survival outcomes in hematological and solid cancers. However the mechanisms suppressing genome instability at the\n                    <jats:italic>BCL6<\/jats:italic>\n                    \u2010MTC preventing\n                    <jats:italic>BCL6<\/jats:italic>\n                    rearragements remain unclear. Here, transcriptome analysis and genome\u2010wide mapping of histone H3 lysine 4 trimethylation (H3K4me3) in hydroxyurea (HU)\u2010treated Raji cells (a Burkitt's lymphoma model) revealed the induced expression of\n                    <jats:italic>MBD1,<\/jats:italic>\n                    encoding the DNA CpG methylation\u2010binding protein. Functional studies using shRNA silencing and ectopic overexpression demonstrated that MBD1 suppresses\n                    <jats:italic>BCL6<\/jats:italic>\n                    transcription whose promoter harbors conserved CpG methylation sites, suggesting a DNA methylation\u2010dependent regulation of\n                    <jats:italic>BCL6<\/jats:italic>\n                    trasncription by MBD1. Conversely, BCL6 repressed\n                    <jats:italic>MBD1<\/jats:italic>\n                    expression by binding to its promoter.\n                    <jats:italic>MBD1<\/jats:italic>\n                    \u2010depleted Raji cells exhibited increased genomic instability at the\n                    <jats:italic>BCL6<\/jats:italic>\n                    \u2010MTC upon HU treatment, heightened sensitivity to DNA replication inhibitors (HU, gemcitabine, and etoposide), and reduced tumorigenicity in xenograft mouse models. We propose that MBD1 prevents genomic instability at the\n                    <jats:italic>BCL6<\/jats:italic>\n                    \u2010MTC to suppress DLBCL formation. Moreover, MBD1 promotes genomic stability and cell viability during DNA replication stress. MBD1 thus represents a potential therapeutic target for cancers exhibiting resistance to chemotherapies targeting DNA replication.\n                  <\/jats:p>","DOI":"10.1002\/hon.70227","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T03:59:17Z","timestamp":1786075157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DNA Replication Stress\u2010Induced Transcriptome of Human Burkitt's Lymphoma Identifies Reciprocal Regulation Between\n                    <i>MBD1<\/i>\n                    and\n                    <i>BCL6<\/i>\n                    During Germinal Center\u2010Derived B\u2010Lymphomagenesis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1787-1190","authenticated-orcid":false,"given":"Santosh Kumar","family":"Gothwal","sequence":"first","affiliation":[{"name":"Institute of Frontier Science Initiative Kanazawa University  Kanazawa Japan"},{"name":"Center for Genomic Integrity Institute for Basic Science  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Oichai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Ulsan National Institute of Science and Technology  Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungjae","family":"Myung","sequence":"additional","affiliation":[{"name":"Center for Genomic Integrity Institute for Basic Science  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline H.","family":"Barlow","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010120419\u2010022408"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(00)00078\u20107"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.07.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201010\u2010464958"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae204"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07064"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u201001102\u20103"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201010\u2010185827"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004906\u20108"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081221"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.20.4645"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.14.6947"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1245"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100244\u20102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235596"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/moh.0b013e328302c7df"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.06.017"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09883"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.61"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609758114"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201006\u2010357996"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.04.011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509343103"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.051"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100204"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013100"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013106"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068768"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.024"},{"key":"e_1_2_10_32_1","article-title":"Stress 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