{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:46:27Z","timestamp":1792406787419,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nucleoporin 98 rearrangements (\n                    <jats:italic>NUP98<\/jats:italic>\n                    re) occur in a wide range of hematologic malignancies including acute leukemias with a variety of fusion partners.\n                    <jats:italic>NUP98<\/jats:italic>\n                    re is associated with adverse prognosis, especially in children. We aimed to better understand the genomics of acute leukemias with\n                    <jats:italic>NUP98<\/jats:italic>\n                    re including fusion partners and co\u2010occurring genomic alterations (GA). Results from 5905 patients with acute leukemia undergoing standard\u2010of\u2010care next generation sequencing on FoundationOneHeme were included for analysis. A total of 78 (1.3%) patient samples harbored\n                    <jats:italic>NUP98<\/jats:italic>\n                    re with a median age of 19\u00a0years compared with 62\u00a0years for the cases with no\n                    <jats:italic>NUP98<\/jats:italic>\n                    rearrangement (\n                    <jats:italic>NUP98<\/jats:italic>\n                    wt) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Patients with\n                    <jats:italic>NUP98<\/jats:italic>\n                    re were more frequently of admixed American ancestry (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Among patients with acute myeloid leukemia, individual genomic alterations more frequently identified in\n                    <jats:italic>NUP98<\/jats:italic>\n                    re cases included\n                    <jats:italic>WT1<\/jats:italic>\n                    (77% vs. 11%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and FLT3 (49% vs. 26%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001); Alterations more frequent in the\n                    <jats:italic>NUP98<\/jats:italic>\n                    wt cohort included\n                    <jats:italic>NPM1<\/jats:italic>\n                    ,\n                    <jats:italic>KMT2A<\/jats:italic>\n                    ,\n                    <jats:italic>TET2, DNMT3A, ASXL1, SRSF2, STAG2,<\/jats:italic>\n                    and\n                    <jats:italic>BCOR<\/jats:italic>\n                    (all\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05).\n                    <jats:italic>NUP98<\/jats:italic>\n                    re are rare in patients with acute leukemia, more frequent in pediatrics and younger adults but distributed across all age groups.\n                    <jats:italic>NUP98<\/jats:italic>\n                    re is associated with a unique genomic landscape featuring increased frequencies of mutations with proliferative features (\n                    <jats:italic>FLT3<\/jats:italic>\n                    and\n                    <jats:italic>KRAS<\/jats:italic>\n                    ) and growth suppression (\n                    <jats:italic>WT1<\/jats:italic>\n                    ). Alterations in\n                    <jats:italic>WT1<\/jats:italic>\n                    had the highest co\u2010occurrence rate in samples containing\n                    <jats:italic>NUP98<\/jats:italic>\n                    re. This work highlights the unique GA associated with\n                    <jats:italic>NUP98<\/jats:italic>\n                    and emphasizes the need for clinical studies to reveal underlying biologic mechanisms and enhance optimal management in the presence of potentially targetable alterations such as\n                    <jats:italic>NUP98<\/jats:italic>\n                    re.\n                  <\/jats:p>","DOI":"10.1002\/hon.70231","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:09:26Z","timestamp":1785323366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape Study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-2441","authenticated-orcid":false,"given":"Osama","family":"Batayneh","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-7160","authenticated-orcid":false,"given":"Natalie","family":"Danziger","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc.  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoudreza","family":"Moein","sequence":"additional","affiliation":[{"name":"Department of Medicine SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour S.","family":"Naji","sequence":"additional","affiliation":[{"name":"Department of Medicine SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-6246","authenticated-orcid":false,"given":"Dean","family":"Pavlick","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc.  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8494-2596","authenticated-orcid":false,"given":"Jeffrey S.","family":"Ross","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc.  Boston Massachusetts USA"},{"name":"Department of Pathology SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Marcus","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc.  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb","family":"Ho","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc.  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gentile","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"City of Hope National Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5461-9777","authenticated-orcid":false,"given":"Lincoln W.","family":"Pasquina","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc.  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