{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:46:29Z","timestamp":1792406789549,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Autologous stem cell transplantation (ASCT) with thiotepa\u2010based conditioning has replaced whole\u2010brain radiotherapy as consolidation for primary central nervous system lymphoma (PCNSL), providing improved efficacy and reduced neurotoxicity. However, the optimal thiotepa\u2010containing regimen remains undefined. We retrospectively analyzed patients aged \u2264 60\u00a0years who underwent ASCT with thiotepa\u2013busulfan\u2013cyclophosphamide (TBC) or busulfan\u2013thiotepa (BuTT) conditioning after high\u2010dose methotrexate\u2013based induction at two Korean institutions between 2015 and 2023. Propensity score matching (PSM;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020 per group) was performed to adjust for baseline differences. Sixty\u2010seven patients were included (TBC,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a030; BuTT,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a037). TBC was associated with significantly longer progression\u2010free survival (PFS) from induction (3\u2010year: 89.9% vs. 72.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.034) and from transplantation (89.9% vs. 69.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.032); overall survival did not differ significantly. In multivariable Cox regression adjusted for pre\u2010transplant response and cumulative MTX exposure, BuTT was independently associated with inferior PFS (HR 4.09, 95% CI 1.27\u201313.18,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.019). After PSM, TBC retained superior PFS (84.7% vs. 73.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.035), with a non\u2010significant trend in Cox analysis (HR 0.22, 95% CI 0.05\u20131.03,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.054). TBC was associated with delayed engraftment and more grade \u2265 3 non\u2010hematologic toxicities, but no treatment\u2010related mortality occurred. In younger patients with PCNSL, TBC demonstrated a trend toward more durable disease control than BuTT, with manageable toxicity. As the thiotepa dose represents the major distinction between regimens, dose\u2010intensified thiotepa strategies with adjusted partner agents merit further prospective investigation.\n                  <\/jats:p>","DOI":"10.1002\/hon.70244","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:28:36Z","timestamp":1788776916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Thiotepa, Busulfan, and Cyclophosphamide Versus Busulfan and Thiotepa Conditioning Regimens in Autologous Stem Cell Transplantation for Primary CNS Lymphoma: A Multicenter Retrospective Analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0745-866X","authenticated-orcid":false,"given":"Eun\u2010Jeong","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Hematology and Oncology Gyeongsang National University Hospital Gyeongsang National University College of Medicine  Jinju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-5297","authenticated-orcid":false,"given":"Sang Eun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\u2010Oncology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-0232","authenticated-orcid":false,"given":"Sang\u2010A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-4401","authenticated-orcid":false,"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\u2010Oncology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-3007","authenticated-orcid":false,"given":"Soo\u2010Mee","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\u2010Oncology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-6372","authenticated-orcid":false,"given":"Jeong\u2010Ok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.357"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008377"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364\u2010021\u201000282\u2010z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(17)30174\u20106"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.18.00306"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2003.05.024"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705452"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.06.2117"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11771"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(16)30050\u20103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.1074"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.09.024"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.09.015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2021.2021073"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010022\u201001605\u2010w"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010025\u201006405\u2010y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.13.524"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702154"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.645208"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.08.024"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010023\u201002071\u20108"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.04.004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010019\u201003667\u20101"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001582\u20105"},{"issue":"1","key":"e_1_2_11_26_1","first-page":"113","article-title":"Cerebrospinal 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